Evidence map›Paper›PMID 27074016›Full record

ArticlePloS one2016

Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.

Laurent Brureau, Dieudonné Moningo, Elise Emeville, Séverine Ferdinand, Augustin Punga, Simon Lufuma, Pascal Blanchet, Marc Romana, Luc Multigner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. African-American Prostate Cancer Disparities.Current urology reports · 2017
    Review
  6. Article
  7. Molecular mechanisms involving prostate cancer racial disparity.American journal of clinical and experimental urology · 2017
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Laurent BrureauInserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.
Dieudonné MoningoService d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
Elise EmevilleInserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.
Séverine FerdinandUniversité des Antilles, Pointe-à-Pitre, Guadeloupe, France.
Augustin PungaService d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
Simon LufumaService d'Urologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo.
Pascal BlanchetInserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.
Marc RomanaUniversité des Antilles, Pointe-à-Pitre, Guadeloupe, France.
Luc MultignerInserm, U1085 - IRSET, Pointe-à-Pitre, Guadeloupe, France.
University of Kinshasa · CDCentre Hospitalier Universitaire Pointe-à-Pitre · GPInserm · FRInstitut de Recherche en Santé, Environnement et Travail · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstrogens are thought to play a critical role in prostate carcinogenesis. It has been suggested that polymorphisms of genes encoding enzymes involved in estrogen metabolism are risk factors for prostate cancer. However, few studies have been performed on populations of African ancestry, which are known to have a high risk of prostate cancer.

objectiveWe investigated whether functional polymorphisms of CYP17, CYP19, CYP1B1, COMT and UGT1A1 affected the risk of prostate cancer in two different populations of African ancestry.

methodsIn Guadeloupe (French West Indies), we compared 498 prostate cancer patients and 565 control subjects. In Kinshasa (Democratic Republic of Congo), 162 prostate cancer patients were compared with 144 controls. Gene polymorphisms were determined by the SNaPshot technique or short tandem repeat PCR analysis. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).

resultsThe AA genotype and the A allele of rs4680 (COMT) appeared to be inversely associated with the risk of prostate cancer in adjusted models for both Afro-Caribbean and native African men. For the A allele, a significant inverse association was observed among cases with low-grade Gleason scores and localized clinical stage, in both populations.

conclusionsThese preliminary results support the hypothesis that polymorphisms of genes encoding enzymes involved in estrogen metabolism may modulate the risk of prostate cancer in populations of African ancestry.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAged, 80 and overAllelesAromataseBlack PeopleCase-Control StudiesCatechol O-MethyltransferaseCytochrome P-450 CYP1B1Democratic Republic of the CongoGenetic Association StudiesGenotypeGlucuronosyltransferaseHumansAromataseCatechol O-MethyltransferaseCOMT protein, humanCYP1B1 protein, humanCytochrome P-450 CYP1B1GlucuronosyltransferaseSteroid 17-alpha-HydroxylaseUGT1A1 Enzyme

Identifiers

PMID27074016
PMCPMC4830606
OpenAlexW2335952386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.