Evidence map›Paper›PMID 27073996›Full record

ArticlePloS one2016

Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei.

Pei-Chen Tsao, Yu-Shih Shiau, Szu-Hui Chiang, Hui-Chen Ho, Yu-Ling Liu, Yuan-Fang Chung, Li-Ju Lin, Ming-Ren Chen, Jia-Kan Chang, Wen-Jue Soong and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pulse oximetry screening for critical congenital heart defects.The Cochrane database of systematic reviews · 2018
    Pooled it
  3. Article
  4. Cardioplegia in Open Heart Surgery: Age Matters.Journal of clinical medicine · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Pei-Chen TsaoDivision of General Pediatrics, Pediatrics Department, Taipei Veterans General Hospital, Taipei, Taiwan.
Yu-Shih ShiauPreventive Medicine Foundation, Taipei, Taiwan.
Szu-Hui ChiangPreventive Medicine Foundation, Taipei, Taiwan.
Hui-Chen HoTaipei Institute of Pathology, Taipei, Taiwan.
Yu-Ling LiuDepartment of Health, Taipei City Government, Taipei, Taiwan.
Yuan-Fang ChungDepartment of Health, Taipei City Government, Taipei, Taiwan.
Li-Ju LinDepartment of Health, Taipei City Government, Taipei, Taiwan.
Ming-Ren ChenMacKay Children's Hospital, Taipei, Taiwan.
Jia-Kan ChangPediatrics Department, Cheng Hsin General Hospital, Taipei, Taiwan.
Wen-Jue SoongDivision of General Pediatrics, Pediatrics Department, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsiu-Lian LinDepartment of Health, Taipei City Government, Taipei, Taiwan.
Betau HwangDepartment of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Kwang-Jen HsiaoPreventive Medicine Foundation, Taipei, Taiwan.
Ministry of Health and Welfare · TWNational Yang Ming Chiao Tung University · TWCheng Hsin General Hospital · TWMackay Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWTaipei City Government · TWTaipei City Hospital · TWTaipei Institute of Pathology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly detection of critical congenital heart disease (CCHD) can significantly reduce morbidity and mortality among newborns. We investigate the feasibility of implementing a community-based newborn CCHD screening program in Taipei.

methodsTwelve birthing facilities in Taipei participated in a trial screening program between October 1, 2013, and March 31, 2014. Newborns underwent pulse oximetry at 24-36 h old, with probes attached to the right hand and one lower limb. Any screening saturation ≥95% in either extremity, with an absolute difference of ≤3% between the right hand and foot, was accepted as a screening pass. A screening result was considered as a fail if the oxygen saturation was <95% at either probe site, on 3 separate occasions, each separated by 30 min or the first result was <95% at either probe site, and any subsequent oxygen saturation measurement was <90%. Public health nurses would follow up all missed or refused cases.

resultsOf the 6,387 live births, 6,296 newborns (coverage rate: 6,296/6,387 = 98.6%) underwent appropriate pulse oximetry screening. Sixteen newborns (0.25%) were reported to have a failed screening result. Five of these screen positive newborns were confirmed with CCHD; two of them were diagnosed solely attributed to the failed screening results. The false-positive rate was 0.18%. Implementing a 6-month screening program for CCHD produced good case detection rate, while using efficient screening and referral systems.

conclusionThis program was successful in integrating screening, referral and public health tracking systems. The protocol outlined in this report could provide a community-based model for worldwide implementation.

Indexed as

Early DiagnosisHeart Defects, CongenitalHumansInfant, NewbornNeonatal ScreeningOximetrySeverity of Illness IndexTaiwan

Identifiers

PMID27073996
PMCPMC4830600
OpenAlexW2338438630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.