Evidence map›Paper›PMID 27073970›Full record

ArticleCognition & emotion2017

Partial replication of two rumination-related candidate gene studies.

Carol A Van Hulle, Sierra Clifford, Mollie N Moore, Kathryn Lemery-Chalfant, H Hill Goldsmith

Erratum issuedAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognition & emotion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Carol A Van Hullea Waisman Center , University of Wisconsin-Madison , Madison , WI , USA.
Sierra Cliffordb Psychology Department , Arizona State University , Tempe , AZ , USA.
Mollie N Moorea Waisman Center , University of Wisconsin-Madison , Madison , WI , USA.
Kathryn Lemery-Chalfantb Psychology Department , Arizona State University , Tempe , AZ , USA.
H Hill Goldsmitha Waisman Center , University of Wisconsin-Madison , Madison , WI , USA.

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 1985 to 2015
$25.2M
LONGITUDINAL TWIN STUDIES OF AFFECTIVE STYLEP50MH069315 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2004 to 2008
$10.4M
Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2013 to 2017
$10.4M
RISK FOR CHILD PSYCHOPATHOLOGY--A TWIN STUDY PERSPECTIVER01MH059785 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2000 to 2011
$4.8M
Validating RDoC for Children and Adolescents: A Twin Study with NeuroimagingR01MH101504 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2014 to 2017
$2.4M
NICHD NIH HHS P30 HD003352NIMH NIH HHS P50 MH069315NIMH NIH HHS P50 MH100031NIMH NIH HHS R01 MH059785NIMH NIH HHS R01 MH101504
6 · The paper itself

Abstract

Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years. Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence. Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. We attempted to replicate and extend these findings in a sample of twins aged 12-16 years. We analyzed the BDNF val66met (rs6265) polymorphism and two (rs242924 and rs7209436) out of three single nucleotide polymorphisms (SNPs) that Woody et al. used to create a CRHR1 haplotype. We controlled for maternal history of depression and clustering within families. Unlike Stone et al., we found higher brooding among BDNF Met carriers. This main effect was qualified by an interaction with pubertal status, with the effect driven by more physically mature participants. Similar to Woody et al., we found an interaction between CRHR1 SNPs and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression. Findings provide partial support for the influence of candidate genes in two environmentally sensitive systems on brooding.

Indexed as

AdolescentBrain-Derived Neurotrophic FactorChildCRF Receptor, Type 1DepressionEndophenotypesFemaleHaplotypesHumansMalePolymorphism, Single NucleotideReceptors, Corticotropin-Releasing HormoneTwinsBDNF protein, humanBrain-Derived Neurotrophic FactorCRF Receptor, Type 1Receptors, Corticotropin-Releasing HormoneadolescenceBDNFBroodingcandidate geneCRHR1depression

Identifiers

PMID27073970
PMCPMC5063675

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.