Evidence map›Paper›PMID 27073489›Full record

ArticleOncology letters2016

Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells.

Luyan Shen, Naiyan Wen, Meihui Xia, Y U Zhang, Weimin Liu, Y E Xu, Liankun Sun

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  5. Metal ions overloading and cell death.Cell biology and toxicology · 2024
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  11. Review
  12. Crosstalk between CaInternational journal of molecular sciences · 2022
    Review
  13. Article
  14. Article
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  16. Review
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  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luyan ShenDepartment of Pathophysiology, Basic College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China; Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun, Jilin 130021, P.R. China.
Naiyan WenDepartment of Pathophysiology, Basic College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China.
Meihui XiaDepartment of Obstetrics and Gynecology, First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China.
Y U ZhangDepartment of Pathophysiology, Basic College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China.
Weimin LiuDepartment of Interventional Radiology, Renmin Hospital, Jilin, Jilin 132013, P.R. China.
Y E XuMedical Research Laboratory, Jilin Medical College, Jilin, Jilin 132013, P.R. China.
Liankun SunDepartment of Pathophysiology, Basic College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China.
Jilin University · CNJilin City Central Hospital · CNJilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of calcium efflux from the endoplasmic reticulum (ER) in cisplatin-induced apoptosis is not fully understood in cancer cells. The present study used western blot analysis, flow cytometry, immunofluorescence and 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay to investigate calcium signaling in human cervical cancer cells exposed to cisplatin. In the present study, treatment with cisplatin increased free Ca

Indexed as

apoptosiscalciumcervical cancercisplatinendoplasmic reticulum stress

Identifiers

PMID27073489
PMCPMC4812401
OpenAlexW2286210882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.