ReviewGastroenterology research and practice2016
Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis.
Review in Gastroenterology research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Evaluating the effect of cigarettes smoking on oesophageal cancer risk: a systematic review and meta-analysis with dose-response relationships.European journal of public health · 2026Pooled it
- Clinicopathological and Perioperative Factors Associated with Overall Survival and 90-Day Mortality Following Esophagectomy for Esophageal Cancer.Journal of clinical medicine · 2026Article
- Unmasking inequalities in gastrointestinal cancer outcomes among Asian American subpopulations.Scientific reports · 2026Article
- Twenty-five years of WWOX insight in cancer: a treasure trove of knowledge.Functional & integrative genomics · 2025Review
- Systematic replication of smoking disease associations using survey responses and EHR data in the All of Us Research Program.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Global burden of esophageal cancer attributable to smoking: a systematic analysis for the Global Burden of Disease Study 2019.Frontiers in oncology · 2023Article
- Review
- Incidence, Survival and Prognostic Factors of Oesophagogastric Cancer.Journal of gastrointestinal cancer · 2022Article
- Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.Nature communications · 2021Article
- Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett's Esophageal Cell Line.International journal of molecular sciences · 2021Article
- Article
- Article
- Using estimated probability of pre-diagnosis behavior as a predictor of cancer survival time: an example in esophageal cancer.BMC medical research methodology · 2020Article
- The Impact of Smoking on Pulmonary Metastasis in Colorectal Cancer.OncoTargets and therapy · 2020Article
- Detection and management of oligometastatic disease in oesophageal cancer and identification of prognostic factors: A systematic review.World journal of gastrointestinal oncology · 2019Article
- Is endoscopic ultrasound examination necessary in the management of esophageal cancer?World journal of gastroenterology · 2017Review
- Malignant Broncho-Oesophageal Fistula following Radiotherapy for Noninvasive T3 Oesophageal Squamous Cell Carcinoma.Case reports in gastroenterologyArticle
- The Diverse Involvement of Cigarette Smoking in Pancreatic Cancer Development and Prognosis.PancreasReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. We conduct the present study to summarize current evidence. A computerized search of the PubMed and EMBASE was performed up to April 30, 2015. Eight studies, containing 4,286 patients, were analyzed. In the grouping analysis, among esophageal squamous-cell carcinoma patients, current and former smokers, compared to those who have never smoked, seemed to have a poorer prognosis (HR = 1.41, 95% CI 1.22-1.64, and HR = 1.35, 95% CI 0.92-1.97, resp.). In the subgroup analysis, adverse effects on current smoker compared with never smoker were also observed in China and the other countries (HR = 1.5, 95% CI 1.18-1.92, and HR = 1.36, 95% CI 1.12-1.65, resp.). In the group that ever smoked, we could not get a similar result. No significantly increased risk was found in esophageal adenocarcinoma patients compared to the squamous-cell histology ones. In the smoking intensity analysis, heavy smoking was associated with poor survival in esophageal squamous-cell carcinoma. Our pooled results supported the existence of harmful effects of smoking on survival after esophagus cancer diagnosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.