ArticleScientific reports2016
Visualization of neonatal lung injury associated with mechanical ventilation using x-ray dark-field radiography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- Realistic wave-optics simulation of X-ray dark-field imaging at a human scale.Scientific reports · 2025Article
- Theoretical and experimental analysis of the modulated phase grating X-ray interferometer.Scientific reports · 2024Article
- Assessment of Inflation in a Human Cadaveric Lung with Dark-Field Chest Radiography.Radiology. Cardiothoracic imaging · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- Emphysema quantified: mapping regional airway dimensions using 2D phase contrast X-ray imaging.Biomedical optics express · 2020Article
- Imaging features in post-mortem x-ray dark-field chest radiographs and correlation with conventional x-ray and CT.European radiology experimental · 2019Article
- A 3-D Projection Model for X-ray Dark-field Imaging.Scientific reports · 2019Article
- Optimization of tube voltage in X-ray dark-field chest radiography.Scientific reports · 2019Article
- Article
- [X‑ray Phase Contrast : Principles, potential and advances in clinical translation].Der Radiologe · 2018Review
- Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.Scientific reports · 2018Article
- X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice.Scientific reports · 2018Article
- A Gaussian extension for Diffraction Enhanced Imaging.Scientific reports · 2018Article
- Article
- Translation from murine to human lung imaging using x-ray dark field radiography: A simulation study.PloS one · 2018Article
- In-vivo X-ray Dark-Field Chest Radiography of a Pig.Scientific reports · 2017Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical ventilation (MV) and supplementation of oxygen-enriched gas, often needed in postnatal resuscitation procedures, are known to be main risk factors for impaired pulmonary development in the preterm and term neonates. Unfortunately, current imaging modalities lack in sensitivity for the detection of early stage lung injury. The present study reports a new imaging approach for diagnosis and staging of early lung injury induced by MV and hyperoxia in neonatal mice. The imaging method is based on the Talbot-Lau x-ray grating interferometry that makes it possible to quantify the x-ray small-angle scattering on the air-tissue interfaces. This so-called dark-field signal revealed increasing loss of x-ray small-angle scattering when comparing images of neonatal mice undergoing hyperoxia and MV-O2 with animals kept at room air. The changes in the dark field correlated well with histologic findings and provided superior differentiation than conventional x-ray imaging and lung function testing. The results suggest that x-ray dark-field radiography is a sensitive tool for assessing structural changes in the developing lung. In the future, with further technical developments x-ray dark-field imaging could be an important tool for earlier diagnosis and sensitive monitoring of lung injury in neonates requiring postnatal oxygen or ventilator therapy.
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