Evidence map›Paper›PMID 27072677›Full record

ArticleCirculation. Cardiovascular quality and outcomes2016

Semi-Competing Risks Data Analysis: Accounting for Death as a Competing Risk When the Outcome of Interest Is Nonterminal.

Sebastien Haneuse, Kyu Ha Lee

Open access · greenAbstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Does lifestyle intervention lower clinically significant cognitive impairment risk?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  4. Trial
  5. Trial
  6. Article
  7. The Effect of Rural Versus Urban Residence on Risk of Unplanned Readmission and Death in Older Veterans Discharged From VA Hospitals.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Observational
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Competing risks data in clinical oncology.Frontiers in oncology · 2024
    Review
  15. Article
  16. Article
  17. Recurrence and Postoperative Death in Patients with Colorectal Cancer: A New Perspective via Semi-competing Risk Framework.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Article
  18. Article
  19. Article
  20. High-Dimensional Survival Analysis: Methods and Applications.Annual review of statistics and its application · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Sebastien HaneuseFrom the Department of Biostatistics, Harvard Chan School of Public Health, Boston, MA (S.H.); and Epidemiology and Biostatistics Core, The Forsyth Institute, Cambridge, MA (K.H.L.). shaneuse@hsph.harvard.edu.
Kyu Ha LeeFrom the Department of Biostatistics, Harvard Chan School of Public Health, Boston, MA (S.H.); and Epidemiology and Biostatistics Core, The Forsyth Institute, Cambridge, MA (K.H.L.).
Cancer Research And Biostatistics · US

Funding

Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Statistical Methods for the Spatio-Temporal Assessment of Social Disparities in CancerP01CA134294 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANEUSE, SEBASTIEN, HERNAN, MIGUEL · 2008 to 2017
$6.8M
Clustered semi-competing risks analysis in quality of end-of-life care studiesR01CA181360 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANEUSE, SEBASTIEN · 2014 to 2017
$1.8M
NCI NIH HHS P01 CA134294NCI NIH HHS R01 CA181360NCI NIH HHS R35 CA197449
6 · The paper itself

Abstract

Hospital readmission is a key marker of quality of health care. Notwithstanding its widespread use, however, it remains controversial in part because statistical methods used to analyze readmission, primarily logistic regression and related models, may not appropriately account for patients who die before experiencing a readmission event within the time frame of interest. Toward resolving this, we describe and illustrate the semi-competing risks framework, which refers to the general setting where scientific interest lies with some nonterminal event (eg, readmission), the occurrence of which is subject to a terminal event (eg, death). Although several statistical analysis methods have been proposed for semi-competing risks data, we describe in detail the use of illness-death models primarily because of their relation to well-known methods for survival analysis and the availability of software. We also describe and consider in detail several existing approaches that could, in principle, be used to analyze semi-competing risks data, including composite end point and competing risks analyses. Throughout we illustrate the ideas and methods using data on N=49 763 Medicare beneficiaries hospitalized between 2011 and 2013 with a principle discharge diagnosis of heart failure.

Indexed as

AgedAged, 80 and overCause of DeathData Interpretation, StatisticalEndpoint DeterminationHeart FailureHumansLogistic ModelsMedicareOdds RatioPatient ReadmissionResearch DesignRisk AssessmentRisk FactorsSurvival AnalysisTime Factorsdeathheart failurereadmissionrisk assessmentsurvival analysis

Identifiers

PMID27072677
PMCPMC4871755
OpenAlexW2337910724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.