Evidence map›Paper›PMID 27072634›Full record

ArticleThe Journal of general virology2016

Recombination among GB virus C (GBV-C) isolates in the United States.

Jason T Blackard, Gang Ma, Clarissa Polen, Juwen C DuBois, Jonathon Gast, Caleb M Radens, Richard K Sterling, Kenneth E Sherman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jason T BlackardDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Gang MaDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Clarissa PolenDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Juwen C DuBoisDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jonathon GastDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Caleb M RadensDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Richard K SterlingDivision of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA.
Kenneth E ShermanDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
University of Cincinnati Medical Center · USVirginia Commonwealth University · US

Funding

HIV Antiretroviral Therapy and Hepatic InjuryR01AI065256 · NIAID · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2006 to 2019
$5.5M
HIV Antiretroviral Therapy and Hepatic InjuryR56AI065256 · NIAID · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2014 to 2014
$535k
Clinical Relevance of GB Virus C & Hepatitis C Virus in HIV+ WomenR21AI081564 · NIAID · UNIVERSITY OF CINCINNATI · PI BLACKARD, JASON T · 2009 to 2010
$430k
NIAID NIH HHS R01 AI065256NIAID NIH HHS R21 AI081564NIAID NIH HHS R56 AI065256
6 · The paper itself

Abstract

GB virus C (GBV-C) is a non-pathogenic flavivirus that may play a role in modulating HIV disease. Multiple genotypes of GBV-C that have been identified to date that may differentially regulate HIV; however, the number of complete GBV-C sequences published to date is very limited. We sequenced full-length GBV-C genomes from four individuals with HIV/HCV co-infection in the United States. Intergenotypic recombination was evident in two of these individuals. Evaluation of additional full-length GBV-C genomes would facilitate the creation of full-length, replication-competent molecular clones of GBV-C to evaluate the phenotypic diversity of GBV-C genotypes and provide important molecular data on this understudied virus.

Indexed as

Amino Acid SequenceBase SequenceCoinfectionFlaviviridae InfectionsGB virus CGenome, ViralHumansPhylogenyProspective StudiesRecombination, GeneticRNA, ViralSequence Analysis, RNAUnited StatesRNA, Viral

Identifiers

PMID27072634
PMCPMC5756482
OpenAlexW2340570799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.