ArticleNeurotoxicity research2016
HIV-1 gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological Disorders.
Article in Neurotoxicity research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.International journal of molecular sciences · 2026Review
- PKR Inhibitor C16 Regulates HIV-gp120 Induced Neuronal Injury and Cognitive Impairment in Vivo and in Vitro Models.Neurochemical research · 2025Article
- Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV.Brain, behavior, and immunity · 2023Article
- HIV-Proteins-Associated CNS Neurotoxicity, Their Mediators, and Alternative Treatments.Cellular and molecular neurobiology · 2022Review
- Viral Vector-Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review.Human gene therapy · 2020Review
- Systemic Mitochondrial Oxidative Phosphorylation Protein Levels Correlate with Neuroimaging Measures in Chronically HIV-Infected Individuals.AIDS research and human retroviruses · 2020Article
- Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND.Journal of neurovirology · 2019Review
- HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders.Progress in neurobiology · 2019Review
- Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- HIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity.Current HIV research · 2018Review
- HIV-1-Associated Atherosclerosis: Unraveling the Missing Link.Journal of the American College of Cardiology · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of HIV infection presents a great challenge among the patients who develop various forms of cognitive impairments. Particularly, the neurotoxicity associated with HIV is attributed to different viral proteins present in HIV, and is a root cause for HIV-associated neurocognitive disorders (HAND). A common characteristic among several neurodegenerative disorders including HAND is mitochondrial dysfunction in various brain cells. However, there has been very little effort to explore the possibility of exploiting mitochondrial dynamics in HAND treatment. A recent study by Avdoshina and colleagues has reported the role of mitochondrial dysfunction in HIV-1 gp120-mediated neuronal dysfunction, which presents a novel mechanism for the development of adjunct therapy to treat HAND.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.