ReviewJournal of neurology2016
Measurement and maintenance of reserve in multiple sclerosis.
Review in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic, Evidence-Based Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple Sclerosis.Neuropsychology review · 2016Pooled it
- Affective reserve in older adults with and without multiple sclerosis: A residual-based approach.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Spinal cord reserve is associated with multi-dimensional clinical resilience in multiple sclerosis.Journal of neurology · 2026Article
- Advancing multiple sclerosis management in older adults.Nature reviews. Neurology · 2025Article
- Premorbid Sociodemographic Status and Multiple Sclerosis Outcomes in a Universal Health Care Context.JAMA network open · 2023Observational
- Personality as a Predictor of Disability in Multiple Sclerosis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis.Journal of neurology · 2022Article
- Drivers of caregiver impact in Duchenne muscular dystrophy: a cohort study.Journal of patient-reported outcomes · 2022Article
- Synaptic Dysfunction in Multiple Sclerosis: A Red Thread from Inflammation to Network Disconnection.International journal of molecular sciences · 2021Review
- Treatment and management of cognitive dysfunction in patients with multiple sclerosis.Nature reviews. Neurology · 2020Review
- Brain activity pattern changes after adaptive working memory training in multiple sclerosis.Brain imaging and behavior · 2020Article
- Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis.Frontiers in neurology · 2020Article
- Recommendations for cognitive screening and management in multiple sclerosis care.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Review
- Evaluation of Tobramycin Exposure Predictions in Three Bayesian Forecasting Programmes Compared with Current Clinical Practice in Children and Adults with Cystic Fibrosis.Clinical pharmacokinetics · 2018Article
- A simple measure of cognitive reserve is relevant for cognitive performance in MS patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Into the Moment: Does Mindfulness Affect Biological Pathways in Multiple Sclerosis?Frontiers in behavioral neuroscience · 2018Article
- Retention of Gadolinium-Based Contrast Agents in Multiple Sclerosis: Retrospective Analysis of an 18-Year Longitudinal Study.AJNR. American journal of neuroradiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive dysfunction is highly prevalent, disabling, and poorly managed in persons with multiple sclerosis (MS). However, not all persons with MS present with cognitive impairment despite having grey and white matter pathology. To explain such an observation, much attention has been drawn to other factors, namely the concept of reserve (i.e., protection against clinical manifestations of neurological damage). There is a growing body of evidence supporting brain reserve and cognitive reserve for mitigating the deleterious effects of MS pathology on cognition in MS. Measurement and maintenance of reserve is paramount. The current review addresses measures of brain and cognitive reserve, separately, that have been adopted in MS research. These measures are largely based on genetics and premorbid behavior. We propose that reserve may not be limited to premorbid factors that are not highly amenable to change. Rather, reserve can be built and maintained over time based on ongoing participation in cognitively stimulating activities. We conclude with recommendations for future research on reserve in MS samples. This will provide keen insight into potential applications for building reserve and ultimately improving the well-being of those with MS across multiple domains.
Indexed as
Identifiers
27072141What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.