ReviewPediatric nephrology (Berlin, Germany)2017
Optimizing response to desmopressin in patients with monosymptomatic nocturnal enuresis.
Review in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Enuresis: practical guidelines for primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Guideline
- Expert consensus on the management of nocturnal enuresis in children.World journal of pediatrics : WJP · 2026Article
- Enuresis in Children.Indian journal of pediatrics · 2026Review
- [Lower urinary tract dysfunction in children].Urologie (Heidelberg, Germany) · 2025Review
- L'évaluation et la prise en charge de l'énurésie en pédiatrie générale.Paediatrics & child health · 2023Review
- Evaluation and management of enuresis in the general paediatric setting.Paediatrics & child health · 2023Review
- The Biology of Vasopressin.Biomedicines · 2021Review
- Pediatric Pharmacology of Desmopressin in Children with Enuresis: A Comprehensive Review.Paediatric drugs · 2020Review
- Nocturia in mothers and enuresis in children: Possible links.Turkish journal of urology · 2020Article
- Exploration of the Optimal Desmopressin Treatment in Children With Monosymptomatic Nocturnal Enuresis: Evidence From a Chinese Cohort.Frontiers in pediatrics · 2020Article
- Pharmacokinetic and Pharmacodynamic Properties of a Micro-Dose Nasal Spray Formulation of Desmopressin (AV002) in Healthy Water-Loaded Subjects.Pharmaceutical research · 2019Article
- Brazilian consensus in enuresis-recomendations for clinical practice.International braz j urol : official journal of the Brazilian Society of UrologyReview
- Modern management of pediatric nocturnal enuresis: Evidence-based treatment and practical guidance.Tzu chi medical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most patients with monosymptomatic nocturnal enuresis can be effectively treated with an enuresis alarm or antidiuretic therapy (desmopressin), depending on the pathophysiology of the condition in the individual patient. Desmopressin is first-line therapy for enuresis caused by nocturnal polyuria, an excessive urine output during the night. However, in a recent study, around one-third of patients thought to be resistant to desmopressin were subsequently treated effectively with desmopressin monotherapy in a specialist centre. The aim of this article is to review best practice in selecting patients for desmopressin treatment, as well as outline eight recommendations for maximizing the chances of treatment success in patients receiving desmopressin. The roles of formulation, dose, timing of administration, food and fluid intake, inter-individual variation in response, body weight, adherence, withdrawal strategies and combination therapies are discussed in light of the most recent research on desmopressin and enuresis. Possible reasons for suboptimal treatment response are explored and strategies to improve outcomes in patients for whom desmopressin is an appropriate therapy are presented. Through optimization of the treatment plan in primary and specialist care centres, the hope is that fewer patients with this distressing and often embarrassing condition will experience unnecessary delays in receiving appropriate care and achieving improvements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.