ArticleHeredity2016
The genetic contribution to sex determination and number of sex chromosomes vary among populations of common frogs (Rana temporaria).
Article in Heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Genome-Wide Characterization of Sex-Linked Regions in the Sangzhi Horned Toad (Boulenophrys sangzhiensis) Reveals Complex Sex Determination Mechanisms.Molecular ecology resources · 2026Article
- A near telomere-to-telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps.GigaScience · 2025Article
- Homology in Sex Determination in Two Distant Spiny Frogs,Animals : an open access journal from MDPI · 2024Article
- Polygenic sex determination in vertebrates - is there any such thing?Trends in genetics : TIG · 2023Review
- Male heterogametic sex determination in Rana dybowskii based on sex-linked molecular markers.Integrative zoology · 2022Article
- A dense linkage map for a large repetitive genome: discovery of the sex-determining region in hybridizing fire-bellied toads (Bombina bombina and Bombina variegata).G3 (Bethesda, Md.) · 2021Article
- Evolution of master sex determiners: TGF-β signalling pathways at regulatory crossroads.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Review
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
- A reciprocal translocation radically reshapes sex-linked inheritance in the common frog.Molecular ecology · 2019Article
- Evolutionary and developmental dynamics of sex-biased gene expression in common frogs with proto-Y chromosomes.Genome biology · 2018Article
- A rapid rate of sex-chromosome turnover and non-random transitions in true frogs.Nature communications · 2018Article
- More sex chromosomes than autosomes in the Amazonian frog Leptodactylus pentadactylus.Chromosoma · 2018Article
- Demographic and genetic consequences of disturbed sex determination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Climate-driven shifts in adult sex ratios via sex reversals: the type of sex determination matters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Comparative High-Density Linkage Mapping Reveals Conserved Genome Structure but Variation in Levels of Heterochiasmy and Location of Recombination Cold Spots in the Common Frog.G3 (Bethesda, Md.) · 2017Article
- Using conventionalPeerJ · 2017Article
- Sex-linked markers in the North American green frog (Rana clamitans) developed using DArTseq provide early insight into sex chromosome evolution.BMC genomics · 2016Article
- Dmrt1 polymorphism covaries with sex-determination patterns in Rana temporaria.Ecology and evolution · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The patterns of sex determination and sex differentiation have been shown to differ among geographic populations of common frogs. Notably, the association between phenotypic sex and linkage group 2 (LG2) has been found to be perfect in a northern Swedish population, but weak and variable among families in a southern one. By analyzing these populations with markers from other linkage groups, we bring two new insights: (1) the variance in phenotypic sex not accounted for by LG2 in the southern population could not be assigned to genetic factors on other linkage groups, suggesting an epigenetic component to sex determination; (2) a second linkage group (LG7) was found to co-segregate with sex and LG2 in the northern population. Given the very short timeframe since post-glacial colonization (in the order of 1000 generations) and its seemingly localized distribution, this neo-sex chromosome system might be the youngest one described so far. It does not result from a fusion, but more likely from a reciprocal translocation between the original Y chromosome (LG2) and an autosome (LG7), causing their co-segregation during male meiosis. By generating a strict linkage between several important genes from the sex-determination cascade (Dmrt1, Amh and Amhr2), this neo-sex chromosome possibly contributes to the 'differentiated sex race' syndrome (strictly genetic sex determination and early gonadal development) that characterizes this northern population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.