SynthesisThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2016
Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review.
Synthesis in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke.Journal of comparative effectiveness research · 2023Pooled it
- Mechanical Thrombectomy for Acute and Subacute Blocked Arteries and Veins in the Lower Limbs: A Health Technology Assessment.Ontario health technology assessment series · 2023Pooled it
- A Systematic Review and Meta-Analysis of Animal Studies Testing Intra-Arterial Chilled Infusates After Ischemic Stroke.Frontiers in neurology · 2020Pooled it
- Economic evaluation of a phase III international randomised controlled trial of very early mobilisation after stroke (AVERT).BMJ open · 2019Trial
- An umbrella review of systematic reviews and meta-analyses evaluating the efficacy and safety of mechanical thrombectomy for acute ischemic stroke.Annals of medicine and surgery (2012) · 2026Article
- Association of Clinical, Radiological, and Procedural Characteristics with NIHSS at Discharge and 90-Day Modified Rankin Scale Outcomes in Individuals with Stroke Treated with Mechanical Thrombectomy.Diagnostics (Basel, Switzerland) · 2026Article
- Safety and Efficacy of Intracranial Stenting in Acute Stroke Patients Using a Pharmacological Treatment Protocol Including Low-Dose Intra-arterial Eptifibatide-A Single-center Retrospective Analysis.Clinical neuroradiology · 2026Article
- Untethered miniature robots for minimally invasive thrombus treatment: From bench to clinical trials.Innovation (Cambridge (Mass.)) · 2025Review
- The economic impact of stent retriever selection for acute ischemic stroke: a cost analysis of MASTRO I from the healthcare system perspective of the United States, Canada and eight European countries.Journal of comparative effectiveness research · 2025Article
- Three-year post-stroke outcomes in urban North-western Tanzania.Frontiers in stroke · 2025Article
- Training a high accuracy model to visualize blood clots during mechanical thrombectomy for the treatment of Acute Ischemic Stroke.Frontiers in stroke · 2025Article
- The impact of Heads Up testing on thrombectomy for acute ischemic stroke.Frontiers in stroke · 2025Article
- Disparities of Mortality Trends Due to Cerebrovascular Diseases and Cerebrovascular Infarction in the United States.Stroke (Hoboken, N.J.) · 2024Article
- Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges.Journal of inflammation research · 2024Review
- Systems-level computational modeling in ischemic stroke: from cells to patients.Frontiers in physiology · 2024Review
- Mechanical thrombectomy for AIS from large vessel occlusion - current trends and future perspectives.Annals of medicine and surgery (2012) · 2023Review
- INFluence of Revascularization Attempts on Clinical Outcomes of Mechanical Thrombectomy Patients and its Economic BURDEN.Stroke (Hoboken, N.J.) · 2022Article
- Efficacy of intravenous thrombolysis combined with mechanical stent interventional thrombectomy on acute ischemic stroke.Journal of medical biochemistry · 2022Article
- De novo headache in ischemic stroke patients treated with thrombectomy: a prospective study.The journal of headache and pain · 2022Article
- CT-based radiomics for differentiating intracranial contrast extravasation from intraparenchymal haemorrhage after mechanical thrombectomy.European radiology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although intravenous thrombolysis increases the probability of a good functional outcome in carefully selected patients with acute ischemic stroke, a substantial proportion of patients who receive thrombolysis do not have a good outcome. Several recent trials of mechanical thrombectomy appear to indicate that this treatment may be superior to thrombolysis. We therefore conducted a systematic review and meta-analysis to evaluate the clinical effectiveness and safety of new-generation mechanical thrombectomy devices with intravenous thrombolysis (if eligible) compared with intravenous thrombolysis (if eligible) in patients with acute ischemic stroke caused by a proximal intracranial occlusion. We systematically searched seven databases for randomized controlled trials published between January 2005 and March 2015 comparing stent retrievers or thromboaspiration devices with best medical therapy (with or without intravenous thrombolysis) in adults with acute ischemic stroke. We assessed risk of bias and overall quality of the included trials. We combined the data using a fixed or random effects meta-analysis, where appropriate. We identified 1579 studies; of these, we evaluated 122 full-text papers and included five randomized control trials (n=1287). Compared with patients treated medically, patients who received mechanical thrombectomy were more likely to be functionally independent as measured by a modified Rankin score of 0-2 (odds ratio, 2.39; 95% confidence interval, 1.88-3.04; I2=0%). This finding was robust to subgroup analysis. Mortality and symptomatic intracerebral hemorrhage were not significantly different between the two groups. Mechanical thrombectomy significantly improves functional independence in appropriately selected patients with acute ischemic stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.