Evidence map›Paper›PMID 27071710›Full record

ArticleBioanalysis2016

Challenges and opportunities for translating medical microdevices: insights from the programmable bio-nano-chip.

Michael P McRae, Glennon Simmons, John T McDevitt

Abstract read
In one paragraph

Article in Bioanalysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael P McRaeDepartment of Bioengineering, Rice University, Houston, TX, USA.
Glennon SimmonsDepartment of Biomaterials, New York University, New York, NY, USA.
John T McDevittDepartment of Bioengineering, Rice University, Houston, TX, USA.

Funding

Effects of Oral Inflammation on the Levels of Salivary Biomarkers of AMIU01DE017793 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI MCDEVITT, JOHN T · 2006 to 2012
$13.0M
NIDCR NIH HHS U01 DE017793
6 · The paper itself

Abstract

This perspective highlights the major challenges for the bioanalytical community, in particular the area of lab-on-a-chip sensors, as they relate to point-of-care diagnostics. There is a strong need for general-purpose and universal biosensing platforms that can perform multiplexed and multiclass assays on real-world clinical samples. However, the adoption of novel lab-on-a-chip/microfluidic devices has been slow as several key challenges remain for the translation of these new devices to clinical practice. A pipeline of promising medical microdevice technologies will be made possible by addressing the challenges of integration, failure to compete with cost and performance of existing technologies, requisite for new content, and regulatory approval and clinical adoption.

Indexed as

Lab-On-A-Chip DevicesPoint-of-Care SystemsEquipment DesignHumansMedical Device LegislationMicrofluidic Analytical Techniqueslab-on-a-chipmHealthmicrofluidic devicespoint-of-care diagnosticsprogrammable bio-nano-chip (p-BNC)

Identifiers

PMID27071710
PMCPMC4870725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.