ArticleGenome biology and evolution2016
Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated Bacteroides vulgatus mpk.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Genome plasticity shapes the ecology and evolution of Phocaeicola dorei and Phocaeicola vulgatus.Scientific reports · 2024Article
- Origins and Evolution of NovelbioRxiv : the preprint server for biology · 2023Article
- Effects ofAnimals : an open access journal from MDPI · 2023Article
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- The Infant Gut CommensalFrontiers in cellular and infection microbiology · 2022Article
- Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe.Cell reports · 2020Article
- Antibiotic Resistance: Moving From Individual Health Norms to Social Norms in One Health and Global Health.Frontiers in microbiology · 2020Review
- A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus.Viruses · 2019Article
- Weak Agonistic LPS Restores Intestinal Immune Homeostasis.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- Streamlined Genetic Manipulation of DiversemBio · 2019Article
- Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.Nature microbiology · 2019Article
- Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses.Frontiers in immunology · 2019Article
- Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing.Gut microbes · 2018Article
- Article
- Microbiome and chronic inflammatory bowel diseases.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Potential Effects of Horizontal Gene Exchange in the Human Gut.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like many other Bacteroides species, Bacteroides vulgatus strain mpk, a mouse fecal isolate which was shown to promote intestinal homeostasis, utilizes a variety of mobile elements for genome evolution. Based on sequences collected by Pacific Biosciences SMRT sequencing technology, we discuss the challenges of assembling and studying a bacterial genome of high plasticity. Additionally, we conducted comparative genomics comparing this commensal strain with the B. vulgatus type strain ATCC 8482 as well as multiple other Bacteroides and Parabacteroides strains to reveal the most important differences and identify the unique features of B. vulgatus mpk. The genome of B. vulgatus mpk harbors a large and diverse set of mobile element proteins compared with other sequenced Bacteroides strains. We found evidence of a number of different horizontal gene transfer events and a genome landscape that has been extensively altered by different mobilization events. A CRISPR/Cas system could be identified that provides a possible mechanism for preventing the integration of invading external DNA. We propose that the high genome plasticity and the introduced genome instabilities of B. vulgatus mpk arising from the various mobilization events might play an important role not only in its adaptation to the challenging intestinal environment in general, but also in its ability to interact with the gut microbiota.
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