Evidence map›Paper›PMID 27071087›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania.

Matteo Martino, Paola Magioncalda, Zirui Huang, Benedetta Conio, Niccolò Piaggio, Niall W Duncan, Giulio Rocchi, Andrea Escelsior, Valentina Marozzi, Annemarie Wolff and 3 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 9 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 9 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Polarisation of brain dynamics in mania and depression.Dialogues in clinical neuroscience · 2026
    Article
  11. Article
  12. Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 5 countries.

Matteo MartinoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Paola MagioncaldaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy; paola.magioncalda@gmail.com georg.northoff@theroyal.ca.
Zirui HuangMind, Brain Imaging, and Neuroethics, Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 7K4;
Benedetta ConioDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Niccolò PiaggioDepartment of Radiology, Section of Neuroradiology, University of Genoa, Genoa 16100, Italy;
Niall W DuncanGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei City 110, Taiwan; Departments of Psychiatry and Radiology, Brain and Consciousness Research Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan; Centre for Cognition and Brain Disorders, Normal University Hangzhou, Hangzhou 31121, China;
Giulio RocchiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Andrea EscelsiorDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Valentina MarozziDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Annemarie WolffMind, Brain Imaging, and Neuroethics, Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 7K4;
Matilde IngleseDepartment of Neurology, Radiology, and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029; Magnetic Resonance Research Center on Nervous System Diseases, University of Genoa, Genoa 16100, Italy;
Mario AmoreDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16100, Italy;
Georg NorthoffMind, Brain Imaging, and Neuroethics, Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 7K4; Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei City 110, Taiwan; Departments of Psychiatry and Radiology, Brain and Consciousness Research Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan; Centre for Cognition and Brain Disorders, Normal University Hangzhou, Hangzhou 31121, China; Research Center for Mind, Brain, and Learning, National Chengchi University, Taipei City 11605, Taiwan; Department of Philosophy and Cognition, Zhejang University, Hangzhou 310015, China; University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada K1Z 7K4 paola.magioncalda@gmail.com georg.northoff@theroyal.ca.
University of Genoa · ITRoyal Ottawa Mental Health Centre · CAHangzhou Normal University · CNTaipei Medical University-Shuang Ho Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depressive and manic phases in bipolar disorder show opposite constellations of affective, cognitive, and psychomotor symptoms. At a neural level, these may be related to topographical disbalance between large-scale networks, such as the default mode network (DMN) and sensorimotor network (SMN). We investigated topographical patterns of variability in the resting-state signal-measured by fractional SD (fSD) of the BOLD signal-of the DMN and SMN (and other networks) in two frequency bands (Slow5 and Slow4) with their ratio and clinical correlations in depressed (n = 20), manic (n = 20), euthymic (n = 20) patients, and healthy controls (n = 40). After controlling for global signal changes, the topographical balance between the DMN and SMN, specifically in the lowest frequency band, as calculated by the Slow5 fSD DMN/SMN ratio, was significantly increased in depression, whereas the same ratio was significantly decreased in mania. Additionally, Slow5 variability was increased in the DMN and decreased in the SMN in depressed patients, whereas the opposite topographical pattern was observed in mania. Finally, the Slow5 fSD DMN/SMN ratio correlated positively with clinical scores of depressive symptoms and negatively with those of mania. Results were replicated in a smaller independent bipolar disorder sample. We demonstrated topographical abnormalities in frequency-specific resting-state variability in the balance between DMN and SMN with opposing patterns in depression and mania. The Slow5 DMN/SMN ratio was tilted toward the DMN in depression but was shifted toward the SMN in mania. The Slow5 fSD DMN/SMN pattern could constitute a state-biomarker in diagnosis and therapy.

Indexed as

Brain MappingMagnetic Resonance ImagingAdolescentAdultAffectBipolar DisorderFemaleHumansMaleMiddle AgedMovementNerve NetOxygenPsychomotor AgitationRestSensationOxygenbipolar disorderdefault mode networkneuronal variabilitysensorimotor network

Identifiers

PMID27071087
PMCPMC4855585
OpenAlexW2338400803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.