ArticlePloS one2016
Comparative Genome Analysis Provides Insights into the Pathogenicity of Flavobacterium psychrophilum.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Research on Prophages in Aquaculture from the Perspective of Paradigm Borrowing: Advances in Pathogen Virulence, Antimicrobial Resistance, and Environmental Regulation.Microorganisms · 2026Review
- Comparative genomics of crucian carp-isolatedFrontiers in microbiology · 2026Article
- Phenotypic and Genotypic Antimicrobial Resistance Profiles of Flavobacterium psychrophilum and Flavobacterium branchiophilum Isolated From Rainbow Trout (Oncorhynchus mykiss) in Slovenia.Journal of fish diseases · 2025Article
- Genetic and phenotypic diversity of Flavobacterium psychrophilum isolates from Czech salmonid fish farms.BMC microbiology · 2024Article
- Evaluating the Safety ofMicroorganisms · 2024Article
- Characterisation of sRNAs enriched in outer membrane vesicles of pathogenicJournal of extracellular biology · 2024Article
- Characterization and Pathogenicity ofMicroorganisms · 2023Article
- Dual RNA-Seq ofPathogens (Basel, Switzerland) · 2023Article
- Genomic evidence of genetic diversity and functional evolution inFrontiers in microbiology · 2023Article
- Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum.Environmental microbiology · 2022Article
- Article
- Comparative Genomic Analyses ofMicroorganisms · 2021Article
- The Type IX Secretion System Is Required for Virulence of the Fish Pathogen Flavobacterium psychrophilum.Applied and environmental microbiology · 2020Article
- Article
- Computational Identification of Repeat-Containing Proteins and Systems.QRB discovery · 2020Article
- Aquaculture as a source of empirical evidence for coevolution between CRISPR-Cas and phage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Identification of a Novel Elastin-Degrading Enzyme from the Fish PathogenApplied and environmental microbiology · 2019Article
- Large-Scale Analysis of Flavobacterium psychrophilum Multilocus Sequence Typing Genotypes Recovered from North American Salmonids Indicates that both Newly Identified and Recurrent Clonal Complexes Are Associated with Disease.Applied and environmental microbiology · 2019Article
- Phenotypic and Genetic Predictors of Pathogenicity and Virulence inFrontiers in microbiology · 2019Article
- Genome analysis provides insights into the epidemiology of infection with Flavobacterium psychrophilum among farmed salmonid fish in Sweden.Microbial genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavobacterium psychrophilum is a fish pathogen in salmonid aquaculture worldwide that causes cold water disease (CWD) and rainbow trout fry syndrome (RTFS). Comparative genome analyses of 11 F. psychrophilum isolates representing temporally and geographically distant populations were used to describe the F. psychrophilum pan-genome and to examine virulence factors, prophages, CRISPR arrays, and genomic islands present in the genomes. Analysis of the genomic DNA sequences were complemented with selected phenotypic characteristics of the strains. The pan genome analysis showed that F. psychrophilum could hold at least 3373 genes, while the core genome contained 1743 genes. On average, 67 new genes were detected for every new genome added to the analysis, indicating that F. psychrophilum possesses an open pan genome. The putative virulence factors were equally distributed among isolates, independent of geographic location, year of isolation and source of isolates. Only one prophage-related sequence was found which corresponded to the previously described prophage 6H, and appeared in 5 out of 11 isolates. CRISPR array analysis revealed two different loci with dissimilar spacer content, which only matched one sequence in the database, the temperate bacteriophage 6H. Genomic Islands (GIs) were identified in F. psychrophilum isolates 950106-1/1 and CSF 259-93, associated with toxins and antibiotic resistance. Finally, phenotypic characterization revealed a high degree of similarity among the strains with respect to biofilm formation and secretion of extracellular enzymes. Global scale dispersion of virulence factors in the genomes and the abilities for biofilm formation, hemolytic activity and secretion of extracellular enzymes among the strains suggested that F. psychrophilum isolates have a similar mode of action on adhesion, colonization and destruction of fish tissues across large spatial and temporal scales of occurrence. Overall, the genomic characterization and phenotypic properties may provide new insights to the mechanisms of pathogenicity in F. psychrophilum.
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