Evidence map›Paper›PMID 27071056›Full record

ArticleScientific data2016

Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts.

Yu-Jie Hu, Anthony N Imbalzano

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The small members of the JMJD protein family: Enzymatic jewels or jinxes?Biochimica et biophysica acta. Reviews on cancer · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yu-Jie HuDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Anthony N ImbalzanoDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
University of Massachusetts Chan Medical School · US

Funding

TRANSCRIPTION FACTOR FUNCTION IN CHROMATINR01GM056244 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IMBALZANO, ANTHONY N · 1997 to 2019
$6.7M
NIGMS NIH HHS GM56244NIGMS NIH HHS R01 GM056244
6 · The paper itself

Abstract

Emerging evidence suggests Jumonji domain-containing proteins are epigenetic regulators in diverse biological processes including cellular differentiation and proliferation. RNA interference-based analyses combined with gene expression profiling can effectively characterize the cellular functions of these enzymes. We found that the depletion of Jumonji domain-containing protein 6 (JMJD6) and its paralog protein Jumonji domain-containing protein 4 (JMJD4) individually by small hairpin RNAs (shRNAs) slowed cell proliferation of mouse NIH3T3 fibroblasts. We subsequently performed gene expression profiling on both JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts using the Affymetrix GeneChip Mouse Exon 1.0 ST Array. Here we report the gene profiling datasets along with the experimental procedures. The information can be used to further investigate how JMJD6 and JMJD4 affect gene expression and cellular physiology.

Indexed as

Gene Expression ProfilingNIH 3T3 CellsAnimalsCell ProliferationFibroblastsGene SilencingJumonji Domain-Containing Histone DemethylasesMiceProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseReceptors, Cell SurfaceRNA, Small InterferingJMJD4 protein, mouseJumonji Domain-Containing Histone DemethylasesProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenasePtdsr protein, mouseReceptors, Cell SurfaceRNA, Small Interfering

Identifiers

PMID27071056
PMCPMC4828940
OpenAlexW2314620236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.