ArticlePloS one2016
Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Increased P-wave dispersion in patients with obstructive sleep apnea syndrome: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- A deep learning-enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Global cognitive function correlates with P-wave dispersion in frail hypertensive older adults.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Signal-averaged P wave area increases during respiratory events in patients with paroxysmal atrial fibrillation and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2019Article
- Right Atrial Deformation Mechanics in Children with Adenotonsillar Hypertrophy.Journal of cardiovascular imaging · 2018Article
- Predictors of heart rhythm disturbances in hypertensive obese patients with obstructive sleep apnea.Journal of geriatric cardiology : JGC · 2017Article
- P-wave dispersion: an update.Indian pacing and electrophysiology journalReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high P-wave duration and dispersion (Pd) have been reported to be a prognostic factor for the occurrence of paroxysmal atrial fibrillation (PAF), a condition linked to obstructive sleep apnea (OSA). We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can be induced by respiratory manoeuvres simulating OSA in healthy subjects and in patients with PAF.
methods12-lead-electrocardiography (ECG) was recorded continuously in 24 healthy subjects and 33 patients with PAF, while simulating obstructive apnea (Mueller manoeuvre, MM), obstructive hypopnea (inspiration through a threshold load, ITH), central apnea (AP), and during normal breathing (BL) in randomized order. The P-wave duration and Pd was calculated by using dedicated software for ECG-analysis.
resultsP-wave duration and Pd significantly increased during MM and ITH compared to BL in all subjects (+13.1 ms and +13.8 ms during MM; +11.7 ms and +12.9 ms during ITH; p<0.001 for all comparisons). In MM, the increase was larger in healthy subjects when compared to patients with PAF (p<0.05).
conclusionIntrathoracic pressure swings through simulated obstructive sleep apnea increase P-wave duration and Pd in healthy subjects and in patients with PAF. Our findings imply that intrathoracic pressure swings prolong the intra-atrial and inter-atrial conduction time and therefore may represent an independent trigger factor for the development for PAF.
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