ArticlePloS one2016
The Effects of Cutaneous Fatty Acids on the Growth of Pseudogymnoascus destructans, the Etiological Agent of White-Nose Syndrome (WNS).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Winter activity of tricolored bats in aboveground and subterranean hibernacula in the southeastern USA.Scientific reports · 2025Article
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- Fatty acid secretion by the white-rot fungus, Trametes versicolor.Journal of industrial microbiology & biotechnology · 2022Article
- Trans-2-hexenal downregulates several pathogenicity genes of Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats.Journal of industrial microbiology & biotechnology · 2021Article
- Hepatic lipid signatures of little brown bats (Myotis lucifugus) and big brown bats (Eptesicus fuscus) at early stages of white-nose syndrome.Scientific reports · 2021Article
- Skin fungal assemblages of bats vary based on susceptibility to white-nose syndrome.The ISME journal · 2021Article
- Skin pH varies among bat species and seasons and between wild and captive bats.Conservation physiology · 2021Article
- Antifungal Potential of the Skin Microbiota of Hibernating Big Brown Bats (Frontiers in microbiology · 2020Article
- Lipolytic Activity and the Utilization of Fatty Acids Associated with Bat Sebum by Pseudogymnoascus destructans.Mycopathologia · 2019Article
- The evolution of a bat population with white-nose syndrome (WNS) reveals a shift from an epizootic to an enzootic phase.Frontiers in zoology · 2019Article
- The Antifungal Properties of Epidermal Fatty Acid Esters: Insights from White-Nose Syndrome (WNS) in Bats.Molecules (Basel, Switzerland) · 2018Article
- Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Galleria mellonella as an insect model for P. destructans, the cause of White-nose Syndrome in bats.PloS one · 2018Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White Nose Syndrome (WNS) greatly increases the over-winter mortality of little brown (Myotis lucifugus), Indiana (Myotis sodalis), northern (Myotis septentrionalis), and tricolored (Perimyotis subflavus) bats. It is caused by a cutaneous infection with the fungus Pseudogymnoascus destructans (Pd). Big brown bats (Eptesicus fuscus) are much more resistant to cutaneous infection with Pd, however. We thus conducted analyses of wing epidermis from hibernating E. fuscus and M. lucifugus to determine their fatty acid compositions, and laboratory Pd culture experiments at 4.0-13.4°C to determine the effects of these fatty acids on Pd growth. Our analyses revealed that the epidermis of both bat species contain the same 7 fatty acid types (14:0, 15:0, 16:0. 16:1, 18:0, 18:1, & 18:2), but the epidermis of M. lucifugus contains: a) more stearic (18:0) acid, b) less palmitoleic (16:1) acid, c) less myristic (14:0) acid, and, d) less oleic (18:1) acid than that of E. fuscus. The growth of Pd was inhibited by: a) myristic and stearic acids at 10.5-13.4°C, but not at 4.0-5.0°C, b) oleic acid at 5.0-10.6°C, c) palmitoleic acid, and, d) linoleic (18:2) acid at 5.0-10.6°C. One set of factors that enables E. fuscus to better resist cutaneous P. destructans infections (and thus WNS) therefore appears to be the relatively higher myristic, palmitoleic, and oleic acid contents of the epidermis.
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