ArticlePLoS genetics2016
Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Preclinical mouse models for studying cholangiocarcinoma.Liver research (Beijing, China) · 2026Review
- Indirect neurogenesis in space and time.Nature reviews. Neuroscience · 2024Review
- MicroRNAs as the critical regulators of epithelial mesenchymal transition in pancreatic tumor cells.Heliyon · 2024Review
- Novel Genome-EngineeredGenes · 2024Article
- A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors ineLife · 2022Article
- Notch signaling regulates neural stem cell quiescence entry and exit in Drosophila.Development (Cambridge, England) · 2022Article
- Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division ofeLife · 2021Article
- Notch Signalling in Breast Development and Cancer.Frontiers in cell and developmental biology · 2021Review
- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- Temporal patterning in neural progenitors: fromDisease models & mechanisms · 2020Review
- Article
- Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57Developmental cell · 2019Article
- Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System.Journal of developmental biology · 2018Review
- LGR5 promotes epithelial ovarian cancer proliferation, metastasis, and epithelial-mesenchymal transition through the Notch1 signaling pathway.Cancer medicine · 2018Article
- Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.Nature cell biology · 2018Article
- Progressive derivation of serially homologous neuroblast lineages in the gnathal CNS of Drosophila.PloS one · 2018Article
- Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms.The Journal of cell biology · 2017Article
- miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial-mesenchymal transition and the Notch signaling pathway.Scientific reports · 2017Article
- Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System.G3 (Bethesda, Md.) · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding challenging. Here, we address the complexity of Notch signaling with respect to proliferation, using the developing Drosophila CNS as model. We find that a Notch/Su(H)/E(spl)-HLH cascade specifically controls daughter, but not progenitor proliferation. Additionally, we find that different E(spl)-HLH genes are required in different neuroblast lineages. The Notch/Su(H)/E(spl)-HLH cascade alters daughter proliferation by regulating four key cell cycle factors: Cyclin E, String/Cdc25, E2f and Dacapo (mammalian p21CIP1/p27KIP1/p57Kip2). ChIP and DamID analysis of Su(H) and E(spl)-HLH indicates direct transcriptional regulation of the cell cycle genes, and of the Notch pathway itself. These results point to a multi-level signaling model and may help shed light on the dichotomous proliferative role of Notch signaling in many other systems.
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