ArticleCancer cell2016
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Cancer cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
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Who cites it
57 citing papers in PubMed, 96 citations in OpenAlex.
- IAP antagonists induce anti-tumor immunity in multiple myeloma.Nature medicine · 2016Trial
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- QRICH1 mediates an intracellular checkpoint for CD8Science immunology · 2025Article
- Review
- Deciphering Key Regulatory Roles of Linear Ubiquitination in Cell Fate Determination and Disease.Research (Washington, D.C.) · 2025Review
- CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.The Biochemical journal · 2024Article
- Advances in biology, diagnosis and treatment of DLBCL.Annals of hematology · 2024Review
- Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy.Cancer cell · 2024Article
- Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas.Blood · 2023Article
- Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery.Cell communication and signaling : CCS · 2023Review
- Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as Part of the EphB4 Degradation Complex Regulated by the Autocrine IGF-II/IRInternational journal of molecular sciences · 2023Article
- Role of K63-linked ubiquitination in cancer.Cell death discovery · 2022Review
- K63 ubiquitination in immune signaling.Trends in immunology · 2022Review
- NF-κB and Pancreatic Cancer; Chapter and Verse.Cancers · 2021Review
- A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma.Leukemia · 2021Article
- Current Methods of Post-Translational Modification Analysis and Their Applications in Blood Cancers.Cancers · 2021Review
- MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis.Blood · 2021Article
- TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.Signal transduction and targeted therapy · 2021Article
- Ubiquitination in the regulation of inflammatory cell death and cancer.Cell death and differentiation · 2021Review
- TNFR2 is required for RIP1-dependent cell death in human leukemia.Blood advances · 2020Article
Corrections and comments
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Authors and funding
25 authors at 10 institutions in 4 countries.
Yibin YangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Priscilla KellyLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Arthur L ShafferLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Roland SchmitzLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Hee Min YooLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Xinyue LiuLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Da Wei HuangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Daniel WebsterLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Ryan M YoungLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Masao NakagawaLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Michele CeribelliLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
George W WrightBiometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yandan YangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Hong ZhaoLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Xin YuLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Weihong XuLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA.
Wing C ChanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Elaine S JaffeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Randy D GascoyneBritish Columbia Cancer Agency, Vancouver, BC V5Z 4E6, Canada.
Elias CampoHospital Clinic, University of Barcelona, 08036 Barcelona, Spain.
Andreas RosenwaldDepartment of Pathology, University of Würzburg, 97080 Würzburg, Germany.
German OttDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany.
Jan DelabieDepartment of Pathology, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Lisa RimszaDepartment of Pathology, University of Arizona, Tucson, AZ 85724, USA.
Louis M StaudtLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N115, Bethesda, MD 20892, USA. Electronic address: lstaudt@mail.nih.gov.
National Cancer Institute · USCenter for Cancer Research · USNational Institutes of Health · USBC Cancer Agency · CACity Of Hope National Medical Center · USRobert Bosch Hospital · DEUniversitat de Barcelona · ESUniversity Health Network · CAUniversity of Arizona · USUniversity of Würzburg · DE
Funding
Oncogenic mechanisms and molecular targets in lymphomaZIABC011008 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI STAUDT, LOUIS · 2009 to 2025
$21.0MOncogenic mechanisms and molecular targets in lymphomaZ01BC011008 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI STAUDT, LOUIS · 2008 to 2008
$770kIntramural NIH HHS Z01 BC011008
Abstract
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate IκB kinase (IKK) and the classical NF-κB pathway. Here we show that the CBM complex includes the E3 ubiquitin ligases cIAP1 and cIAP2, which are essential mediators of BCR-dependent NF-κB activity in ABC DLBCL. cIAP1/2 attach K63-linked polyubiquitin chains on themselves and on BCL10, resulting in the recruitment of IKK and the linear ubiquitin chain ligase LUBAC, which is essential for IKK activation. SMAC mimetics target cIAP1/2 for destruction, and consequently suppress NF-κB and selectively kill BCR-dependent ABC DLBCL lines, supporting their clinical evaluation in patients with ABC DLBCL.
Indexed as
Adaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsBaculoviral IAP Repeat-Containing 3 ProteinB-Cell CLL-Lymphoma 10 ProteinB-LymphocytesBridged Bicyclo Compounds, HeterocyclicCARD Signaling Adaptor ProteinsCaspasesCell Line, TumorCRISPR-Cas SystemsDipeptidesEnzyme ActivationGene DosageGene Expression ProfilingGene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBaculoviral IAP Repeat-Containing 3 ProteinB-Cell CLL-Lymphoma 10 ProteinBCL10 protein, humanBIRC2 protein, humanBIRC3 protein, humanbirinapantBridged Bicyclo Compounds, HeterocyclicCARD11 protein, humanCARD Signaling Adaptor ProteinsCaspasesDIABLO protein, humanDipeptidesGuanylate CyclaseI-kappa B KinaseIndolesInhibitor of Apoptosis ProteinsIntracellular Signaling Peptides and ProteinsMALT1 protein, humanMitochondrial ProteinsMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinMultiprotein ComplexesNeoplasm ProteinsNF-kappa BReceptors, Antigen, B-CellSM 164TriazolesUbiquitin-Protein Ligases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.