ArticlePLoS genetics2016
Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Mitochondrial stress activates ELT-2-dependent lysosomal proteostasis to extend lifespan inScience advances · 2026Article
- Genome-wide characterization of theFrontiers in plant science · 2026Article
- A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans.Aging cell · 2025Article
- A lysosomal surveillance response promotes healthspan inMetabolism open · 2025Article
- The geroprotective potential of chalcones.Nature communications · 2025Review
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- A lysosomal surveillance response to stress extends healthspan.Nature cell biology · 2025Article
- Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans.Scientific reports · 2024Article
- Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.Nature aging · 2024Article
- In vivo neuroprotective capacity of a Dunaliella salina extract - comprehensive transcriptomics and metabolomics study.NPJ science of food · 2024Article
- Identification of transcription factor high accumulation DNA zones.BMC bioinformatics · 2023Article
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- Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response.Nature communications · 2023Article
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- Evolution of Developmental GATA Factors in Nematodes.Journal of developmental biology · 2020Article
- Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing inG3 (Bethesda, Md.) · 2020Article
- Review
- Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging.GeroScience · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To understand the molecular processes underlying aging, we screened modENCODE ChIP-seq data to identify transcription factors that bind to age-regulated genes in C. elegans. The most significant hit was the GATA transcription factor encoded by elt-2, which is responsible for inducing expression of intestinal genes during embryogenesis. Expression of ELT-2 decreases during aging, beginning in middle age. We identified genes regulated by ELT-2 in the intestine during embryogenesis, and then showed that these developmental genes markedly decrease in expression as worms grow old. Overexpression of elt-2 extends lifespan and slows the rate of gene expression changes that occur during normal aging. Thus, our results identify the developmental regulator ELT-2 as a major driver of normal aging in C. elegans.
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