ArticleTranslational psychiatry2016
Serum BDNF levels before and after the development of mood disorders: a case-control study in a population cohort.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
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- Circulating inflammatory and neurotrophic markers as moderators and/or mediators of cognitive remediation outcome in people with bipolar disorders.BJPsych open · 2024Article
- A study of roflumilast treatment on functional and structural changes in hippocampus in depressed Adult male Wistar rats.PloS one · 2024Article
- Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies.Physiological research · 2022Review
- CCRT and aerobic exercise: a randomised controlled study of processing speed, cognitive flexibility, and serum BDNF expression in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders.Molecular neurobiology · 2022Review
- Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.Clinical nutrition research · 2021Review
- Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.Cell proliferation · 2020Review
- miRNAs in depression vulnerability and resilience: novel targets for preventive strategies.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression.Open access Macedonian journal of medical sciences · 2019Article
- Brain-derived neurotrophic factor as a possible predictor of electroconvulsive therapy outcome.Translational psychiatry · 2019Observational
- Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients.Respiratory research · 2019Article
- Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.Psychiatry research · 2019Article
- Association ofInternational journal of clinical and experimental pathology · 2018Article
- The Alteration of Irisin-Brain-Derived Neurotrophic Factor Axis Parallels Severity of Distress Disorder in Bronchial Asthma Patients.Frontiers in neuroscience · 2017Article
- Alteration of the irisin-brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients.International journal of chronic obstructive pulmonary disease · 2017Article
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case-control study nested in a cohort of 1276 women aged 75-84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history). A total of 106 representative non-depressed controls were also identified in the 2012 follow-up. We assayed BDNF levels in preserved sera of cases and controls at baseline and at follow-up. Serum BDNF levels at baseline in cases of MDD, minDD or minDE with MDE history were no lower than those in controls. The decrease in the serum BDNF level from baseline to follow-up was greater in cases of MDD or minDE with MDE history than in controls or cases of minDD. These results show that serum BDNF levels are not a trait marker of MDD in old women but appeared to be a state marker. The different changes in BDNF levels among diagnostic groups suggest that MDD has a pathophysiologic relation to minDE with MDE history, rather than to minDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.