Evidence map›Paper›PMID 27070409›Full record

Trial reportTranslational psychiatry2016

Training sensory signal-to-noise resolution in children with ADHD in a global mental health setting.

J Mishra, R Sagar, A A Joseph, A Gazzaley, M M Merzenich

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01772485 (Double Blind Randomized Controlled Trial Evaluation of a Novel Brain Plasticity-based Training Program for the Remediation of Cognitive Deficits in Adolescents With ADHD in New Delhi, India), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01772485 nacompletednot on this map

Double Blind Randomized Controlled Trial Evaluation of a Novel Brain Plasticity-based Training Program for the Remediation of Cognitive Deficits in Adolescents With ADHD in New Delhi, India

TypeinterventionalSponsorPosit Science CorporationRan2013 to 2015Enrolled31ConditionsAttention Deficit Hyperactivity DisorderArmsCognitive Training, Active Control
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

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  2. Closed-Loop Neurofeedback of α Synchrony during Goal-Directed Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

J MishraSandler Neurosciences Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
R SagarDepartment of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
A A JosephDepartment of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
A GazzaleySandler Neurosciences Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
M M MerzenichPosit Science Corporation, San Francisco, CA, USA.
All India Institute of Medical Sciences · INUniversity of California, San Francisco · USPosit Science (United States) · US

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
FIC NIH HHS 5R24TW007988-05FIC NIH HHS R24 TW007988
6 · The paper itself

Abstract

Children with attention deficit/hyperactivity disorder (ADHD) have impaired focus on goal-relevant signals and fail to suppress goal-irrelevant distractions. To address both these issues, we developed a novel neuroplasticity-based training program that adaptively trains the resolution of challenging sensory signals and the suppression of progressively more challenging distractions. We evaluated this sensory signal-to-noise resolution training in a small sample, global mental health study in Indian children with ADHD. The children trained for 30 h over 6 months in a double-blind, randomized controlled trial. Training completers showed steady and significant improvements in ADHD-associated behaviors from baseline to post training relative to controls, and benefits sustained in a 6-month follow-up. Post-training cognitive assessments showed significant positive results for response inhibition and Stroop interference tests in training completers vs controls, while measures of sustained attention and short-term memory showed nonsignificant improvement trends. Further, training-driven improvements in distractor suppression correlated with the improved ADHD symptoms. This initial study suggests utility of signal-to-noise resolution training for children with ADHD; it emphasizes the need for further research on this intervention and substantially informs the design of a larger trial.

Indexed as

AttentionAttention Deficit Disorder with HyperactivityChildCognitionComputer-Assisted InstructionCuesDouble-Blind MethodExecutive FunctionFemaleFollow-Up StudiesGoalsHumansIndiaMaleNeuronal PlasticityNeuropsychological Tests

Identifiers

PMID27070409
PMCPMC4872403
OpenAlexW2339464862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.