Evidence map›Paper›PMID 27070332›Full record

ReviewCurrent opinion in allergy and clinical immunology2016

Are genetic tests informative in predicting food allergy?

Jin Li, S Melkorka Maggadottir, Hakon Hakonarson

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The Impact ofDiagnostics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Review
  7. HLA Polymorphisms and Food Allergy Predisposition.Journal of pediatric genetics · 2020
    Review
  8. The Genetics of Food Allergy.Current allergy and asthma reports · 2018
    Review
  9. International journal of inflammation · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jin LiaCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA bDepartment of Immunology, Landspitali University Hospital, Reykjavik, Iceland cDivision of Human Genetics, The Children's Hospital of Philadelphia dThe Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
S Melkorka Maggadottir
Hakon Hakonarson
National University Hospital of Iceland · ISChildren's Hospital of Philadelphia · US

Funding

The Future of Genomics Medicine in Patient Care: Contributions from CHOPU01HG008684 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2015 to 2019
$5.0M
Integrative Analysis of a GWAS Repository with EMRs from over 40,000 ChildrenU01HG006830 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2012 to 2014
$3.7M
NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG008684
6 · The paper itself

Abstract

purpose of reviewFood allergy is common among children and adults worldwide. Recent studies have improved our understanding of the genetic mechanism of food allergy and further studies may result in clinical application through genetic testing. RECENT

findingsGenetic factors are important in the development of food allergy. An increasing number of genes have been associated with food allergy in recent years. These include mutations and genetic variants in the filaggrin gene, the association of human leukocyte antigen DR and DQ regions with food allergy, copy number variation impacting CTNNA3 and RBFOX1, DNA methylation that partially mediates single nucleotide polymorphism association at the HLA-DR and DQ loci, as well as other genes. Several studies have implicated differences in gut microbiota composition in food allergy. SUMMARY: With the advance of high-throughput genotyping and sequencing techniques together with improved analytical methods, the contributions of genetic and environmental factors in development of food allergy are being clarified. Yet much remains to be explored and more studies with larger sample sizes, better phenotyping, and improved quality control genomics methods are needed. The ultimate goal is the development of a panel of reliable markers for genetic testing in food allergy to improve overall patient care.

Indexed as

Genetic TestingGenotypeAdultAnimalsChildFilaggrin ProteinsFood HypersensitivityGene-Environment InteractionHigh-Throughput Nucleotide SequencingHumansPredictive Value of TestsPrognosisFilaggrin Proteins

Identifiers

PMID27070332
PMCPMC5407010
OpenAlexW2337148945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.