ArticlePloS one2016
Assessment of the Genetic Diversity of Different Job's Tears (Coix lacryma-jobi L.) Accessions and the Active Composition and Anticancer Effect of Its Seed Oil.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 87 citations in OpenAlex.
- Coix lacryma-jobi root extract exhibits self-toxicity, with butyl palmitate being the primary toxic substance.BMC plant biology · 2025Article
- Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.Pharmaceutical biology · 2025Article
- Effects of Multi-Generational Rearing on Job's Tears on the Performance and Host Plant Preference ofInsects · 2025Article
- Enhancement of apoptosis in HCT116 and HepG2 cells byChinese herbal medicines · 2025Article
- Effects of the plant growth-promoting rhizobacterium Zobellella sp. DQSA1 on alleviating salt-alkali stress in job's tears seedings and its growth-promoting mechanism.BMC plant biology · 2025Article
- Anti-Pruritic and Immunomodulatory Effects of Coix [International journal of molecular sciences · 2024Article
- The Performances of Adlay (Tropical life sciences research · 2024Article
- Physicochemical and nutritional profiles of wild adlay (Food chemistry: X · 2024Article
- Construction of a high-density genetic map based on large-scale marker development in Coix lacryma-jobi L. using specific-locus amplified fragment sequencing (slaf-seq).Scientific reports · 2024Article
- Effect of Different EdibleFoods (Basel, Switzerland) · 2024Article
- Assembly and comparative genome analysis of four mitochondrial genomes fromFrontiers in plant science · 2024Article
- Review
- Estimation of pollen dispersal distance in Job's tears (Breeding science · 2023Article
- The Differences of Nutrient Components in Edible and Feeding Coix Seed at Different Developmental Stages Based on a Combined Analysis of Metabolomics.Molecules (Basel, Switzerland) · 2023Article
- Changes in Triacylglycerols Content and Quality Control Implications of Coix Seeds during Processing and Storage.Foods (Basel, Switzerland) · 2022Article
- Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health.Molecules (Basel, Switzerland) · 2022Review
- Adlay, an ancient functional plant with nutritional quality, improves human health.Frontiers in nutrition · 2022Review
- Anti-Cancer Properties of Coix Seed Oil against HT-29 Colon Cells through Regulation of the PI3K/AKT Signaling Pathway.Foods (Basel, Switzerland) · 2021Article
- Adlay Testa (Molecules (Basel, Switzerland) · 2021Article
- Increases of Lipophilic Antioxidants and Anticancer Activity of Coix Seed Fermented byFoods (Basel, Switzerland) · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Job's tears (Coix lachryma-jobi L.) is an important crop used as food and herbal medicine in Asian countries. A drug made of Job's tears seed oil has been clinically applied to treat multiple cancers. In this study, the genetic diversity of Job's tears accessions and the fatty acid composition, triglyceride composition, and anti-proliferative effect of Job's tears seed oil were analyzed using morphological characteristics and ISSR markers, GC-MS, HPLC-ELSD, and the MTT method. ISSR analysis demonstrated low genetic diversity of Job's tears at the species level (h = 0.21, I = 0.33) and the accession level (h = 0.07, I = 0.10), and strong genetic differentiation (GST = 0.6702) among all accessions. It also clustered the 11 accessions into three cultivated clades corresponding with geographical locations and two evidently divergent wild clades. The grouping patterns based on morphological characteristics and chemical profiles were in accordance with those clustered by ISSR analysis. Significant differences in morphological characteristics, fatty acid composition, triglyceride composition, and inhibition rates of seed oil were detected among different accessions, which showed a highly significant positive correlation with genetic variation. These results suggest that the seed morphological characteristics, fatty acid composition, and triglyceride composition may be mainly attributed to genetic factors. The proportion of palmitic acid and linoleic acid to oleic acid displayed a highly significant positive correlation with the inhibition rates of Job's tears seed oil for T24 cells, and thus can be an important indicator for quality control for Job's tears.
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