ArticleMolecular therapy. Nucleic acids2016
Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain.
Article in Molecular therapy. Nucleic acids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Oxytocin attenuates the retrieval of methamphetamine-associated reward memories by enhancing adult hippocampal neurogenesis in mice.Molecular psychiatry · 2025Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation.Nature communications · 2024Article
- Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.iScience · 2023Article
- Advances toward precision therapeutics for developmental and epileptic encephalopathies.Frontiers in neuroscience · 2023Review
- Engineering a switchable single-chain TEV protease to control protein maturation in living neurons.Bioengineering & translational medicine · 2022Article
- The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.Nature communications · 2019Article
- The rabbit as a behavioral model system for magnetic resonance imaging.Journal of neuroscience methods · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlling gene expression in mammalian brain is of utmost importance to causally link the role of gene function to cell circuit dynamics under normal conditions and disease states. We have developed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches for inducible and reversible control of gene expression in a cell type specific and brain subregion selective manner. Here, we characterize a two-virus approach to efficiently and reliably switch gene expression on and off, repetitively, both in vitro and in vivo. Our recombinant adeno-associated virus (rAAV)-Tet approach is highly flexible and it has great potential for application in basic and biomedical neuroscience research and gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.