Evidence map›Paper›PMID 27069965›Full record

ArticleJournal of renal injury prevention2016

Role of S-methylisothiourea (SMT) in renal ischemia/reperfusion injury in rats.

Fatemeh Kanani, Faezeh Fazelnia, Mohaddeseh Mojarradfard, Mehdi Nematbakhsh, Fatemeh Moslemi, Fatemeh Eshraghi-Jazi, Ardeshir Talebi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of renal injury prevention, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fatemeh KananiWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Faezeh FazelniaWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohaddeseh MojarradfardWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehdi NematbakhshWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan MN Institute of Basic & Applied Sciences Research, Isfahan, Iran.
Fatemeh MoslemiWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh Eshraghi-JaziWater & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir TalebiDepartment of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExcessive production of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) is associated in renal ischemia reperfusion injury (IRI).

objectivesThis study was designed to investigate the role of S-methylisothiourea (SMT) as selective inhibitor iNOS in renal IRI. MATERIALS AND

methodsMale Wistar rats were subjected to 45 minutes of bilateral renal ischemia by occlusion of renal vessels of both kidney followed by 24 hours of reperfusion. Prior to renal IRI, the rats received either vehicle (saline, group 2) or SMT (50 mg/kg, group 3), and were compared with the sham-operated animals (group 1). At the end of reperfusion period, the rats were sacrificed for kidney tissue pathology investigation.

resultsSerum creatinine (Cr), blood urea nitrogen (BUN), nitrite levels, and kidney weight significantly increased in groups 2 and 3 (P < 0.05). Kidney tissue damage scores in groups 2 and 3 were also higher than that in the sham-operated group (P < 0.05).

conclusionSMT not only prevent the kidney during IRI, but also promotes kidney function disturbance and severity of renal injury.

Indexed as

Nitric oxideRenal injuryRenal ischemia reperfusionS-methylisothiourea

Identifiers

PMID27069965
PMCPMC4827383
OpenAlexW2295076467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.