Evidence map›Paper›PMID 27069933›Full record

ArticleJournal of diabetes research2016

Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.

Cailin Yu, Jeremy C Burns, William H Robinson, Paul J Utz, Peggy P Ho, Lawrence Steinman, Alan B Frey

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Advanced Delivery Strategies for Immunotherapy in Type I Diabetes Mellitus.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Cailin YuDepartment of Cell Biology, New York University Langone School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Jeremy C BurnsDepartment of Cell Biology, New York University Langone School of Medicine, 550 First Avenue, New York, NY 10016, USA.
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Geriatric Research Education and Clinical Center, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Paul J UtzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Peggy P HoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lawrence SteinmanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alan B FreyDepartment of Cell Biology, New York University Langone School of Medicine, 550 First Avenue, New York, NY 10016, USA.
New York University · USStanford University · USGeriatric Research Education and Clinical Center · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
Control of proximal T Cell Receptor signaling in tumor infiltrating lymphocytes.F31CA162875 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BURNS, JEREMY CARLOS · 2011 to 2014
$131k
NCI NIH HHS 5F31CA162875NCI NIH HHS F31 CA162875NCI NIH HHS P30 CA016087NCI NIH HHS P30CA016087NIAID NIH HHS HHSN272201300006CPHS HHS HHSN272201300006C
6 · The paper itself

Abstract

Type 1 diabetes is an autoimmune disease in which insulin-producing pancreatic islet β cells are the target of self-reactive B and T cells. T cells reactive with epitopes derived from insulin and/or IGRP are critical for the initiation and maintenance of disease, but T cells reactive with other islet antigens likely have an essential role in disease progression. We sought to identify candidate CD8(+) T cell epitopes that are pathogenic in type 1 diabetes. Proteins that elicit autoantibodies in human type 1 diabetes were analyzed by predictive algorithms for candidate epitopes. Using several different tolerizing regimes using synthetic peptides, two new predicted tolerogenic CD8(+) T cell epitopes were identified in the murine homolog of the major human islet autoantigen zinc transporter ZnT8 (aa 158-166 and 282-290) and one in a non-β cell protein, dopamine β-hydroxylase (aa 233-241). Tolerizing vaccination of NOD mice with a cDNA plasmid expressing full-length proinsulin prevented diabetes, whereas plasmids encoding ZnT8 and DβH did not. However, tolerizing vaccination of NOD mice with the proinsulin plasmid in combination with plasmids expressing ZnT8 and DβH decreased insulitis and enhanced prevention of disease compared to vaccination with the plasmid encoding proinsulin alone.

Indexed as

Epitopes, T-LymphocyteImmune ToleranceVaccinationAnimalsAutoantibodiesCation Transport ProteinsCD8-Positive T-LymphocytesCells, CulturedDiabetes Mellitus, Type 1Disease Models, AnimalDopamine beta-HydroxylaseFemaleGenetic TherapyHumansInsulin-Secreting CellsLymphocyte ActivationAutoantibodiesCation Transport ProteinsDopamine beta-HydroxylaseEpitopes, T-LymphocyteProinsulinSLC30A8 protein, humanVaccines, SubunitVaccines, SyntheticZinc Transporter 8

Identifiers

PMID27069933
PMCPMC4812430
OpenAlexW2296900915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.