ArticleJournal of diabetes research2016
Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis).
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Tree shrews as a new animal model for systemic sclerosis research.Frontiers in immunology · 2024Article
- Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing.Zoological research · 2021Article
- A Novel Tree Shrew Model of Diabetic Retinopathy.Frontiers in endocrinology · 2021Article
- Regeneration of islet β-cells in tree shrews and rats.Animal models and experimental medicine · 2018Article
- Establishment of basal cell carcinoma animal model in Chinese tree shrew (Zoological research · 2017Article
- Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring.Cell research · 2017Article
- Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
Determining the liver changes during the early stages of diabetes is critical to understand the nature of the disease and development of novel treatments for it. Advances in the use of animal models and next-generation sequencing technologies offer a powerful tool in connection between liver changes and the diabetes. Here, we created a tree shrew diabetes model akin to type 1 diabetes by using streptozotocin to induce hyperglycemia and hyperlipidemia. Using RNA-seq, we compiled liver transcriptome profiles to determine the differentially expressed genes and to explore the role of hyperglycemia in liver changes. Our results, respectively, identified 14,060 and 14,335 genes in healthy tree shrews and those with diabetes, with 70 genes differentially expressed between the two groups. Gene orthology and KEGG annotation revealed that several of the main biological processes of these genes were related to translational processes, steroid metabolic processes, oxidative stress, inflammation, and hypertension, all of which are highly associated with diabetes and its complications. These results collectively suggest that STZ induces hyperglycemia in tree shrew and that hyperglycemia induced oxidative stress led to high expression of aldose reductase, inflammation, and even cell death in liver tissues during the early stage of diabetes.
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