ArticleMaxillofacial plastic and reconstructive surgery2016
Comparison of unprocessed silk cocoon and silk cocoon middle layer membranes for guided bone regeneration.
Article in Maxillofacial plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of Sericin Content on the Structural Characteristics and Properties of New Silk Nonwoven Fabrics.Biomolecules · 2023Article
- Fabrication, Structure, and Properties of Nonwoven Silk Fabrics Prepared with Different Cocoon Layers.International journal of molecular sciences · 2023Article
- Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.International journal of molecular sciences · 2022Article
- Retrospective comparative clinical study for silk mat application into extraction socket.Maxillofacial plastic and reconstructive surgery · 2019Article
- Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery.Animals : an open access journal from MDPI · 2019Article
- The effects of proteins released from silk mat layers on macrophages.Maxillofacial plastic and reconstructive surgery · 2018Article
- Bone regeneration is associated with the concentration of tumour necrosis factor-α induced by sericin released from a silk mat.Scientific reports · 2017Article
- Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug.Tissue engineering and regenerative medicine · 2017Article
- Silk Fibroin-Alginate-Hydroxyapatite Composite Particles in Bone Tissue Engineering Applications In Vivo.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilk cocoon is composed of multiple layers. The natural silk cocoon containing all layers was cut as a rectangular shape as defined as total group. The inner and outermost layers were removed from the total group and the remained mat was defined as the middle group. The objectives of this study was to compare the total group with the middle group as a barrier membrane for the guided bone regeneration.
methodsThe effects of these materials on the cellular proliferation and alkaline phosphatase (ALP) expression of MG63 cells were explored. For comparing bone regeneration ability, bilateral bone defects were created in calvarial areas in ten adult New Zealand white rabbits. The defects were covered with silk membranes of the middle group, with silk membrane of the total group used as the control on the contralateral side. The defects were allowed to heal for 4 and 8 weeks. Micro-computerized tomography (μCT) and histological examination were performed.
resultsThe middle group exhibited a higher MTT value 48 and 72 h after treatment compared to the total group. ALP expression was also higher in the middle group. The results of μCT and histologic examination showed that new bone formation was significantly higher in the middle group compared to the total group 8 weeks postoperatively (
conclusionsIn conclusion, the middle layer of the silk cocoon supports guided bone regeneration better than unprocessed silk cocoon.
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