Evidence map›Paper›PMID 27069849›Full record

ArticleMedical mycology case reports2016

Two echinocandin-resistant Candida glabrata FKS mutants from South Africa.

Serisha D Naicker, Rindidzani E Magobo, Thokozile G Zulu, Tsidiso G Maphanga, Nkosinathi Luthuli, Warren Lowman, Nelesh P Govender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Ibrexafungerp: A narrative overview.Current research in microbial sciences · 2024
    Review
  3. Article
  4. Pan-Echinocandin ResistantJournal of fungi (Basel, Switzerland) · 2022
    Article
  5. Antifungal Resistance in Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2021
    Review
  6. Review
  7. Review
  8. Article
  9. F1000Research · 2016
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Serisha D NaickerNational Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
Rindidzani E MagoboFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Thokozile G ZuluNational Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
Tsidiso G MaphangaNational Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa.
Nkosinathi LuthuliLife Parklands, Springs, South Africa.
Warren LowmanFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Vermaak and Partners Pathologists, Johannesburg, South Africa.
Nelesh P GovenderNational Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections, a Division of the National Health Laboratory Service, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1 and FKS2 genes. In this report, we describe the first two South African C. glabrata isolates with echinocandin resistance mediated by mutations in the FKS2 gene. Both isolates were cultured from urine specimens from private-sector patients.

Indexed as

Candida glabrataEchinocandin resistanceSouth Africa

Identifiers

PMID27069849
PMCPMC4811853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.