Evidence map›Paper›PMID 27069768›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2016

[(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease.

Kacie D Deters, Shannon L Risacher, Karmen K Yoder, Adrian L Oblak, Frederick W Unverzagt, Jill R Murrell, Francine Epperson, Eileen F Tallman, Kimberly A Quaid, Martin R Farlow and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Cognitive Decline: Not Always Alzheimer's Disease.Journal of Alzheimer's disease reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kacie D DetersCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of MedicineIndianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of MedicineIndianapolis, IN, USA.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of MedicineIndianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA.
Karmen K YoderCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of MedicineIndianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA.
Adrian L OblakIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Pathology and Laboratory Medicine, Indiana University School of MedicineIndianapolis, IN, USA.
Frederick W UnverzagtIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Psychiatry, Indiana University School of MedicineIndianapolis, IN, USA.
Jill R MurrellIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Pathology and Laboratory Medicine, Indiana University School of MedicineIndianapolis, IN, USA.
Francine EppersonIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Pathology and Laboratory Medicine, Indiana University School of MedicineIndianapolis, IN, USA.
Eileen F TallmanCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of MedicineIndianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA.
Kimberly A QuaidIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of MedicineIndianapolis, IN, USA.
Martin R FarlowIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Neurology, Indiana University School of MedicineIndianapolis, IN, USA.
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of MedicineIndianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Psychiatry, Indiana University School of MedicineIndianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of MedicineIndianapolis, IN, USA; Department of Neurology, Indiana University School of MedicineIndianapolis, IN, USA.
Bernardino GhettiIndiana Alzheimer Disease Center, Indiana University School of MedicineIndianapolis, IN, USA; Department of Psychiatry, Indiana University School of MedicineIndianapolis, IN, USA; Department of Pathology and Laboratory Medicine, Indiana University School of MedicineIndianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of MedicineIndianapolis, IN, USA; Department of Neurology, Indiana University School of MedicineIndianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Sensory and Perceptual Measures as Biomarkers of Alzheimer's Disease PathologyK01AG049050 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI RISACHER, SHANNON L · 2015 to 2019
$612k
NCATS NIH HHS UL1 TR001108NIA NIH HHS K01 AG049050NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019771
6 · The paper itself

Abstract

Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh Compound B (PiB) positron emission tomography (PET) is capable of detecting PrP-amyloid in PRNP gene carriers. Six individuals at risk for GSS and eight controls underwent [(11)C]PiB PET scans using standard methods. Approximately one year after the initial scan, each of the three asymptomatic carriers (two with PRNP P102L mutation, one with PRNP F198S mutation) underwent a second [(11)C]PiB PET scan. Three P102L carriers, one F198S carrier, and one non-carrier of the F198S mutation were cognitively normal, while one F198S carrier was cognitively impaired during the course of this study. No [(11)C]PiB uptake was observed in any subject at baseline or at follow-up. Neuropathologic study of the symptomatic individual revealed PrP-immunopositive plaques and tau-immunopositive neurofibrillary tangles in cerebral cortex, subcortical nuclei, and brainstem. PrP deposits were also numerous in the cerebellar cortex. This is the first study to investigate the ability of [(11)C]PiB PET to bind to PrP-amyloid in GSS F198S subjects. This finding suggests that [(11)C]PiB PET is not suitable for in vivo assessment of PrP-amyloid plaques in patients with GSS.

Indexed as

[11C]Pittsburgh compound B (PiB) positron emission tomography (PET)amyloidGerstmann-Sträussler-Scheinker disease (GSS)neuroimagingprion disease

Identifiers

PMID27069768
PMCPMC4749507
OpenAlexW2338727013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.