ArticleSurgical neurology international2016
Thalassemia, extramedullary hematopoiesis, and spinal cord compression: A case report.
Article in Surgical neurology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review.Annals of medicine · 2022Pooled it
- An extramedullary hematopoietic lesion causing acute lumbar stenosis in the setting of sickle cell anemia: a case report and review of the literature.Journal of spine surgery (Hong Kong) · 2025Article
- Article
- A Rare Case of Cord Compression From Extra-Medullary Hematopoiesis (EMH) in Beta Thalassemia.Cureus · 2023Article
- Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Intracranial extramedullary hematopoiesis in a patient with beta-thalassemia presenting with head trauma.Surgical neurology international · 2022Article
- Unusual presentation of extramedullary haematopoiesis in a young boy.BMJ case reports · 2019Article
- Compressive Dorsal Myelopathy Secondary to Extramedullary Hematopoiesis in a Thalassemic Patient.Case reports in neurological medicine · 2019Article
- Lung masses in a thalassemia patient: A diagnostic dilemma.Journal of Taibah University Medical Sciences · 2018Article
- Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria.Malaria journal · 2018Article
- Spinal cord compression secondary to extramedullary hematopoiesis: A rareness in a young adult with thalassemia major.Acta bio-medica : Atenei Parmensis · 2017Article
- Extramedullary Hematopoiesis Presenting with Thoracic Spinal Cord Compression in a Young Adult with Thalassemia Major: A Case Report.Journal of pediatric neurosciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtramedullary hematopoiesis (EMH) refers to hematopoiesis outside of the medulla of the bone. Chronic anemia states such as thalassemia can cause hematopoietic tissue to expand in certain locations. We report a case of spinal cord compression due to recurrent spinal epidural EMH, which was treated with a combination of surgery and radiotherapy. Pakistan has one of the highest incidence and prevalence of thalassemia in the world. We describe published literature on diagnosis and management of such cases. CASE DESCRIPTION: An 18-year-old male presented with bilateral lower limb paresis. He was a known case of homozygous beta thalassemia major. He had undergone surgery for spinal cord compression due to EMH 4 months prior to presentation. Symptom resolution was followed by deterioration 5 days later. He was operated again at our hospital with complete resection of the mass. He underwent local radiotherapy to prevent recurrence. At 2 years follow-up, he showed complete resolution of symptoms. Follow-up imaging demonstrated no residual mass.
conclusionThe possibility of EMH should be considered in every patient with ineffective erythropoiesis as a cause of spinal cord compression. Treatment of such cases is usually done with blood transfusions, which can reduce the hematopoietic drive for EMH. Other options include surgery, hydroxyurea, radiotherapy, or a combination of these on a case to case basis.
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