ArticleCanadian journal of kidney health and disease2016
Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study.
Article in Canadian journal of kidney health and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hyponatremia Following Antipsychotic Treatment: In Silico Pharmacodynamics Analysis of Spontaneous Reports From the US Food and Drug Administration Adverse Event Reporting System Database and an Updated Systematic Review.The international journal of neuropsychopharmacology · 2021Pooled it
- Comparative Risk of Hyponatremia Among Patients Treated With Second-Generation Antipsychotics.JAMA network open · 2026Article
- Case report: the challenges of psychogenic polydipsia.Oxford medical case reports · 2025Article
- A drug-based model to predict hyponatremia in outpatients of a geriatric clinic.European journal of clinical pharmacology · 2025Article
- Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single-center retrospective study.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Identification of risk factors associated with hyponatremia in psychiatric patients: a case-control study.Medicine and pharmacy reports · 2022Article
- Psychotropic drug-induced hyponatremia: results from a drug surveillance program-an update.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Extreme hyponatraemia due to primary polydipsia and quetiapine-induced SIAD.Endocrinology, diabetes & metabolism case reports · 2021Article
- Hyponatremia in Association With Second-Generation Antipsychotics: A Systematic Review of Case Reports.Ochsner journal · 2018Review
- Cariprazine Exhibits Anxiolytic and Dopamine D3 Receptor-Dependent Antidepressant Effects in the Chronic Stress Model.The international journal of neuropsychopharmacology · 2017Article
- Hyponatremia Is a Common Cause.Deutsches Arzteblatt international · 2017Article
- The Hyponatremia Epidemic: A Frontier Too Far?Frontiers in cardiovascular medicine · 2016Review
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Authors and funding
7 authors.
Funding
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Abstract
backgroundA number of case reports have suggested a possible association between atypical antipsychotic medications and hyponatremia. Currently, there are no reliable estimates of hyponatremia risk from atypical antipsychotic drugs.
objectiveThe objective of this study was to examine the 30-day risk of hospitalization with hyponatremia in older adults dispensed an atypical antipsychotic drug relative to no antipsychotic use.
designThe design of this study was a retrospective, population-based cohort study.
settingThe setting of this study was in Ontario, Canada, from 2003 to 2012. PATIENTS: Adults 65 years or older with an identified psychiatric condition who were newly dispensed risperidone, olanzapine, or quetiapine in the community setting compared to adults with similar indicators of baseline health who were not dispensed such a prescription. MEASUREMENTS: The primary outcome was the 30-day risk of hospitalization with hyponatremia. The tracer outcome (an outcome that is not expected to be influenced by the study drugs) was the 30-day risk of hospitalization with bowel obstruction. These outcomes were assessed using hospital diagnosis codes.
methodsUsing health administrative data, we applied a propensity score technique to match antipsychotic users 1:1 to non-users of antipsychotic drugs (58,008 patients in each group). We used conditional logistic regression to compare outcomes among the matched users and non-users.
resultsA total of 104 baseline characteristics were well-balanced between the two matched groups. Atypical antipsychotic use compared to non-use was associated with an increased risk of hospitalization with hyponatremia within 30 days (86/58,008 (0.15 %) versus 53/58,008 (0.09 %); relative risk 1.62 (95 % confidence interval (CI) 1.15 to 2.29); absolute risk increase 0.06 % (95 % CI 0.02 to 0.10)). The limited number of events precluded some additional analyses to confirm if the association was robust. Atypical antipsychotic use compared to non-use was not associated with hospitalization with bowel obstruction within 30 days (55/58,008 (0.09 %) versus 44/58,008 (0.08 %); relative risk 1.25 (95 % CI 0.84 to 1.86)). LIMITATIONS: We could only study older adults within our data sources.
conclusionsIn this study, the use of an atypical antipsychotic was associated with a modest but statistically significant increase in the 30-day risk of a hospitalization with hyponatremia. The association was less pronounced than that described with other psychotropic drugs.
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