ArticleAmerican journal of translational research2016
TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA).Epigenetics · 2025Article
- Guilu erxian glue improves sperm quality in oligasthenospermia mice by promoting TDRP methylation and regulating the cAMP/PKA pathway.Scientific reports · 2025Article
- Genitourinary defects, anxiety and aggressive-like behavior and glucose metabolism disorders inFrontiers in cell and developmental biology · 2025Article
- Higher waist circumference is associated with increased likelihood of female infertility: NHANES 2017-2020 results.Frontiers in endocrinology · 2023Article
- Four novel genes associated with longevity found in Cane corso purebred dogs.BMC veterinary research · 2022Article
- Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.Frontiers in genetics · 2022Article
- Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line.The Journal of reproduction and development · 2020Article
- From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21.PLoS genetics · 2019Article
- Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.Human genome variation · 2017Article
- LncRNACell transplantationArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TDRP (Testis Development-Related Protein), a nuclear factor, might play an important role in spermatogenesis. However, the molecular mechanisms of TDRP underlying these fundamental processes remain elusive. In this study, a Tdrp-deficient mouse model was generated. Fertility tests and semen analysis were performed. Tdrp-deficient mice were not significantly different from wild-type littermates in development of testes, genitourinary tract, or sperm count. Morphologically, spermatozoa of the Tdrp-deficient mice was not significantly different from the wild type. Several sperm motility indexes, i.e. the average path velocity (VAP), the straight line velocity (VSL) and the curvilinear velocity (VCL) were significantly decreased in Tdrp-deficient mice (p<0.05). The proportion of slow velocity sperm also increased significantly in the mutant mice (p<0.05). However, fertility tests showed that no significant difference inaverage offspring amount (AOA), frequency of copulatory plug (FCP), and frequency of conception (FC). Furthermore, TDRP1 could interact with PRM2, which might be the molecular mechanism of its nuclear function in spermatozoa. In conclusion, these data collectively demonstrated that Tdrp deficiency impaired the sperm motility, but Tdrp deficiency alone was not sufficient to cause male infertility in mice. Additionally, TDRP1 might participate in spermatogenes is through interaction with PRM2.
Indexed as
Identifiers
27069551PMC4759427W2345648331What OpenQuestion holds
Registered trials
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