Evidence map›Paper›PMID 27069539›Full record

ArticleAmerican journal of translational research2016

Der f 21, a novel allergen from dermatophagoides farina.

Yulan Wu, Congli Jiang, Meng Li, Haiqiong Yu, Xiaojun Xiao, Xiaoqin Fan, Jianli Lin, Xiaoyu Liu, Min Zhang, Pingchang Yang and 1 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yulan WuOtolaryngology Institutes, Allergy and Immunology Research Center, Shenzhen UniversityShenzhen 518060, China; The State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine3688 Nanhai Blvd., Shenzhen 518060, China.
Congli JiangOtolaryngology Institutes, Allergy and Immunology Research Center, Shenzhen UniversityShenzhen 518060, China; The State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine3688 Nanhai Blvd., Shenzhen 518060, China.
Meng LiThe State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine 3688 Nanhai Blvd., Shenzhen 518060, China.
Haiqiong YuThe State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine 3688 Nanhai Blvd., Shenzhen 518060, China.
Xiaojun XiaoThe State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine 3688 Nanhai Blvd., Shenzhen 518060, China.
Xiaoqin FanShenzhen Kay Laboratory of Shenzhen, Shenzhen Longgang Central Hospital, ENT Institute Shenzhen, China.
Jianli LinThe State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine 3688 Nanhai Blvd., Shenzhen 518060, China.
Xiaoyu LiuOtolaryngology Institutes, Allergy and Immunology Research Center, Shenzhen UniversityShenzhen 518060, China; The State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine3688 Nanhai Blvd., Shenzhen 518060, China.
Min ZhangThe State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine 3688 Nanhai Blvd., Shenzhen 518060, China.
Pingchang YangOtolaryngology Institutes, Allergy and Immunology Research Center, Shenzhen UniversityShenzhen 518060, China; The State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine3688 Nanhai Blvd., Shenzhen 518060, China.
Zhigang LiuOtolaryngology Institutes, Allergy and Immunology Research Center, Shenzhen UniversityShenzhen 518060, China; The State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen University School of Medicine3688 Nanhai Blvd., Shenzhen 518060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Dermatophagoides farina (D. farina) allergens are an important factor contributing to allergic disease. To identify new allergens is important for diagnosis and treatment of allergic diseases. In this study, we sought to characterize the biological activity of Der f 21 of D. farina. The recombinant Der f 21 protein was characterized by western-blot, ELISA and Skin prick test using clinic patient's serum.An allergic asthma mouse model was established with the rDer f 21 as a specific antigen. The results showed that the sera from 28.9% in 38 dust mite allergic children displayed positive results in response to rDer f 21, and 42% in 98 dust mite allergic patients displayed positive response in skin prick test. In addition, Immune inhibition assays showed there was IgE cross-reactivity between rDer f 21 and rDer f 5. Moreover, an allergic asthma mouse model was established. Airway hyperresponsiveness, serum specific IgE, IgG1, eosinophil infiltration in the allergic mice, interleukin-4(IL-4) and interferon-γ (INF-γ) from spleen cells were markedly increased in the allergic mice. The results demonstrate that Der f 21 is a novel allergen.

Indexed as

airwayAllergenbiological activityDer f 21dust mite

Identifiers

PMID27069539
PMCPMC4759415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.