ArticleCurrent therapeutic research, clinical and experimental2015
Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial.
Article in Current therapeutic research, clinical and experimental, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial.Journal of evidence-based integrative medicineTrial
- Comparative Study on the Prokinetic Effects of Ginger, Caraway, and Peppermint in Relieving Gastrointestinal Disturbances in Pulmonary TB Patients: A Clinical Trial.Food science & nutrition · 2025Article
- Use of Traditional Japanese Herbal Medicine Daikenchuto for the Treatment of Abdominal Distention in Very-Low-Birth-Weight Infants.Journal of clinical medicine · 2024Article
- Kampo medicine in ICUs in Japan between 2010 and 2020.Journal of anesthesia · 2023Article
- Daikenchuto significantly improves stool consistency and lower gastrointestinal symptoms in patients with chronic constipation.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Herbal Approaches to Pediatric Functional Abdominal Pain.Children (Basel, Switzerland) · 2022Review
- Efficacy and Safety of the Japanese Herbal Medicine Daikenchuto (DKT) in Elderly Fecal Incontinence Patients: A Prospective Study.Journal of the anus, rectum and colon · 2022Article
- Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials.Nutrients · 2018Review
- Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects.International journal of chronic diseases · 2018Article
- Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone.BioMed research international · 2017Article
- Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCPhytotherapy research : PTR · 2017Article
- Reduction in exacerbation of COPD in patients of advanced age using the Japanese Kampo medicine Dai-kenchu-to: a retrospective cohort study.International journal of chronic obstructive pulmonary diseaseObservational
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDaikenchuto (DKT), a traditional Japanese herbal medicine, is widely used for treatment of gastrointestinal disorders. We evaluated the efficacy and safety of DKT for abdominal bloating in patients with chronic constipation.
objectiveTo evaluate the efficacy and safety of DKT for the treatment of abdominal bloating.
methodsAfter discontinuing as-needed use of laxatives, 10 patients received oral DKT for 14 days (15 g/d). To evaluate small intestinal bacteria overgrowth (SIBO), a glucose breath test was performed before and after treatment with DKT. Before beginning the treatment, 4 patients (40%) had a diagnosis of SIBO based on a positive glucose breath test result. In both the SIBO and non-SIBO groups, bowel movement frequency and stool form remained unchanged after DKT treatment.
resultsFor all patients, median total Gastrointestinal Symptoms Rating Scale score and the median Gastrointestinal Symptoms Rating Scale indigestion and constipation subscales were significantly decreased, whereas the median visual analog score for decreased abdominal bloating was significantly increased. Improvements of those symptoms were the same in both the SIBO and non-SIBO groups, indicating that DKT does not have effects on small intestine bacteria. No serious side effects were reported.
conclusionsDKT treatment improved quality of life for patients with chronic constipation regardless of the presence of SIBO and showed no effects on small intestine bacteria. UMIN Clinical Trial Registry identifier: UMIN000008070.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.