Evidence map›Paper›PMID 27069498›Full record

ReviewNutrition & metabolism2016

Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity.

Md Ashraful Alam, Nusrat Subhan, Hemayet Hossain, Murad Hossain, Hasan Mahmud Reza, Md Mahbubur Rahman, M Obayed Ullah

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition & metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 2 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 2 syntheses or guidelines pooled it, 350 citations in OpenAlex.

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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Md Ashraful AlamDepartment of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, Bangladesh.
Nusrat SubhanSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales Australia.
Hemayet HossainBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Murad HossainDepartment of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, Bangladesh.
Hasan Mahmud RezaDepartment of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, Bangladesh.
Md Mahbubur RahmanDepartment of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, Bangladesh.
M Obayed UllahDepartment of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, Bangladesh.ORCID 0000-0002-1175-3636
North South University · BDBangladesh Council of Scientific and Industrial Research · BDCharles Sturt University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, caffeic acid, chlorgenic acid, and rosmarinic acid belong to this class. These phenolic compounds possess potent antioxidant and anti-inflammatory properties. These compounds were also showed potential therapeutic benefit in experimental diabetes and hyperlipidemia. Recent evidences also suggest that they may serve as valuable molecule for the treatment of obesity related health complications. In adipose tissues, hydroxycinnamic acid derivatives inhibit macrophage infiltration and nuclear factor κB (NF-κB) activation in obese animals. Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-α (TNFα), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Furthermore, hydroxycinnamic acid derivatives also prevent adipocyte differentiation and lower lipid profile in experimental animals. Through these diverse mechanisms hydroxycinnamic acid derivatives reduce obesity and curtail associated adverse health complications.

Indexed as

DiabetesDyslipidemiaHydroxycinnamic acidInflammationObesity

Identifiers

PMID27069498
PMCPMC4827240
OpenAlexW2335264184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.