Evidence map›Paper›PMID 27069420›Full record

ArticleThe Cochrane database of systematic reviews2016

Alternative agents versus prophylactic platelet transfusion for preventing bleeding in patients with thrombocytopenia due to chronic bone marrow failure: a network meta-analysis and systematic review.

Michael Desborough, Lise J Estcourt, Anna Chaimani, Carolyn Doree, Sally Hopewell, Marialena Trivella, Andreas V Hadjinicolaou, Paresh Vyas, Simon J Stanworth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cochrane database of systematic reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Michael DesboroughHaematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Lise J EstcourtHaematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Anna ChaimaniDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Carolyn DoreeSystematic Review Initiative, NHS Blood and Transplant, Oxford, UK.
Sally HopewellOxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.
Marialena TrivellaCentre for Statistics in Medicine, University of Oxford, Oxford, UK.
Andreas V HadjinicolaouHuman Immunology Unit, Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Paresh VyasMRC Molecular Haematology Unit and Department of Haematology, University of Oxford and Oxford University Hospitals NHS Trust, Oxford, UK.
Simon J StanworthNational Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK.
NHS Blood and Transplant · GBUniversity of Oxford · GBOxford University Hospitals NHS Trust · GBUniversity of Ioannina · GR

Funding

Cancer Research UK 16895Department of Health 13/89/09Department of Health SRP/13/89/09
6 · The paper itself

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To compare the relative efficacy of different treatments for thrombocytopenia (artificial platelet substitutes, platelet-poor plasma, fibrinogen, rFVIIa, rFXIII, thrombopoietin mimetics, antifibrinolytic drugs or platelet transfusions) in patients with chronic bone marrow failure and to derive a hierarchy of potential alternate treatments to platelet transfusions.

Identifiers

PMID27069420
PMCPMC4826602
OpenAlexW2275394914

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.