ArticleActa ortopedica brasileira
Effect of hyaluronic acid on chondrocyte apoptosis.
Article in Acta ortopedica brasileira. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis.Frontiers in cell and developmental biology · 2025Review
- Histological features of knee osteoarthritis treated with triamcinolone acetonide and hyaluronic acid.Biomedical reports · 2023Article
- Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.Molecules (Basel, Switzerland) · 2022Article
- Effects ofExperimental and therapeutic medicine · 2021Article
- Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis.Molecular medicine reports · 2020Article
- Article
- The association between different molecular weights of hyaluronic acid and CHAD, HIF-1α, COL2A1 expression in chondrocyte cultures.Experimental and therapeutic medicine · 2018Article
- Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading.PloS one · 2017Article
- In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage.In vitro cellular & developmental biology. Animal · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the percentage of apoptotic cells in a contusion model of osteoarthritis (OA) and to assess whether intra-articular injection of high doses of hyaluronic acid (HA) immediately after trauma reduces chondrocyte apoptosis.
methodsForty knees from adult rabbits were impacted thrice with a 1 kg block released through a 1 meter tall cylinder (29.4 Joules). Subsequently, 2 mL of HA was injected in one knee and 2 mL saline in the contra-lateral knee. Medication were administered twice a week for 30 days, when animals were sacrificed. Specimens were prepared for optical microscopy exam and terminal deoxynucleotidyl transferase end labeling assay (TUNEL).
resultsThe apoptosis rate in the contusion model was 68.01% (± 19.73%), a higher rate than previously described. HA significantly reduced the rate of apoptosis to 53.52% (± 18.09) (p <0.001).
conclusionIntra-articular HA administration started immediately after trauma reduces impact-induced chondrocyte apoptosis rates in rabbits.
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Registered trials
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