ArticleIndian journal of clinical biochemistry : IJCB2016
Plasma Voriconazole Estimation by HPLC.
Article in Indian journal of clinical biochemistry : IJCB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Factors associated with beyond-therapeutic serum voriconazole trough level among critically ill patients with invasive fungal infections.BMC infectious diseases · 2025Article
- High-performance liquid chromatographic method for determination of voriconazole in pure and gel formulation.PloS one · 2024Article
- Article
- Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections.Pharmaceutics · 2023Review
- Comparison of LC-MSMolecules (Basel, Switzerland) · 2022Article
- A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole.Antimicrobial agents and chemotherapy · 2021Article
- Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Voriconazole, an antifungal drug exhibiting wide inter-individual variability, is an ideal candidate for therapeutic drug monitoring (TDM). The aim of the present study was to standardize a simple, sensitive and rapid high performance liquid chromatography (HPLC) method with ultraviolet detection to determine plasma voriconazole concentration. The HPLC method consisted of a combination of acetonitrile and water (7:3) as mobile phase with 1 ml/min flow rate and detection at 255 nm. Plasma protein precipitation was carried out using perchloric acid and the filtered supernatant was passed through C18 column (250 × 4.6 mm, 5 μm) for the separation of voriconazole. The limit of quantification of voriconazole was 0.2 mg/L. The assay was validated with a linearity of 0.2-15 mg/L and used clinically for TDM in patient samples. The inter-assay precision was below 15 % for routine quality control samples. Weight based voriconazole doses were prescribed to 26 patients for empirical treatment of invasive fungal infections. Voriconazole therapy was managed from the baseline drug levels and follow up analysis reflected achievement in clinical efficacy. Routine TDM of voriconazole may reduce adverse events and improve the treatment response in invasive fungal infections.
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