Evidence map›Paper›PMID 27069033›Full record

ArticleLaboratory medicine2016

Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman.

Bryan Steussy, Jacqueline Lekostaj, Qining Qian, Nancy Rosenthal, Carol J Holman, Sergei Syrbu, Benjamin Darbro, Aaron Bossler, Nitin J Karandikar

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bryan SteussyDepartment of Pathology, University of Iowa, Iowa City.
Jacqueline LekostajDepartment of Pathology, University of Iowa, Iowa City.
Qining QianDepartment of Pathology, University of Iowa, Iowa City.
Nancy RosenthalDepartment of Pathology, University of Iowa, Iowa City.
Carol J HolmanDepartment of Pathology, University of Iowa, Iowa City.
Sergei SyrbuDepartment of Pathology, University of Iowa, Iowa City.
Benjamin DarbroDepartment of Pathology, University of Iowa, Iowa City.
Aaron BosslerDepartment of Pathology, University of Iowa, Iowa City.
Nitin J KarandikarDepartment of Pathology, University of Iowa, Iowa City nitin-karandikar@uiowa.edu.
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
6 · The paper itself

Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

Indexed as

5-MethylcytosineB-LymphocytesCell LineageCell TransdifferentiationClone CellsFemaleHistiocytesHumansKaryotypeLeukemia, Monocytic, AcuteLymphoma, FollicularMiddle Aged5-MethylcytosineB cellhistiocyticleukemialymphomasarcomatransdifferentiation

Identifiers

PMID27069033
PMCPMC7243928
OpenAlexW2313246612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.