Evidence map›Paper›PMID 27068648›Full record

ArticleEuropean journal of pediatrics2016

A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants.

Naoya Fukushima, Kenji Nanao, Hiroyuki Fukushima, Akira Namera, Masaru Miura

Abstract readCase Reports
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In one paragraph

Article in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Naoya FukushimaDepartment of Cardiology, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu-shi, Tokyo, 183-8561, Japan.
Kenji NanaoDepartment of Pediatrics, Hino Municipal Hospital, 4-3-1, Tamadaira, Hino-shi, Tokyo, 191-0062, Japan.
Hiroyuki FukushimaDepartment of Pediatrics, Keio University Hospital, 25 Shinano-machi, Shinjunku-ku, Tokyo, 160-8582, Japan.
Akira NameraDepartment of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Kaumi 1-2-3, Minami-ku, Hiroshima, 734-8551, Japan.
Masaru MiuraDepartment of Cardiology, Tokyo Metropolitan Children's Medical Center, 2-8-29, Musashidai, Fuchu-shi, Tokyo, 183-8561, Japan. masaru_miura@tmhp.jp.
Tokyo Metropolitan Children's Medical Center · JPHiroshima University · JPKeio University Hospital · JPNagano Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledIt is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP.

conclusionWhen mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP. WHAT IS KNOWN: •Tricyclic antidepressant can prolong the QT interval. It may be used for depression in pregnancy. What is New: •This is the first neonatal case report of prolonged QT interval and TdP caused by clomipramine transferred transplacentally from the mother.

Indexed as

Abnormalities, Drug-InducedAntidepressive Agents, TricyclicClomipramineDepressionFemaleHumansInfant, NewbornLong QT SyndromeMalePregnancyPrenatal Exposure Delayed EffectsAntidepressive Agents, TricyclicClomipramineClomipramineDesmethylclomipraminePlacental passageProlonged QT intervalTorsades de Pointes

Identifiers

PMID27068648
OpenAlexW2335968796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.