Evidence map›Paper›PMID 27068631›Full record

Trial reportJournal of the American Heart Association2016

Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.

Yousef Rezaei, Kamal Khademvatani, Behzad Rahimi, Mehran Khoshfetrat, Nasim Arjmand, Mir-Hossein Seyyed-Mohammadzad

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02070679 phase3completednot on this map

Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

TypeinterventionalSponsorUrmia University of Medical SciencesRan2014 to 2015Enrolled284ConditionsStable Angina, Unstable Angina, Non ST Segment Elevation Myocardial Infarction, Post MIArmsVitamin E
NCT03755700 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Antioxidants for Preventing Contrast-Induced Acute Kidney Injury After Coronary Artery Catheterization

TypeinterventionalSponsorRajaie Cardiovascular Medical and Research CenterRan2018 to 2019Enrolled1,000ConditionsCoronary Artery Disease, Coronary Artery Angiography, Coronary Catheterization, Contrast-induced NephropathyArmsVitamin E, N-acetyl cysteine, Placebo oral capsule, Placebos, Normal Saline Flush, 0.9% Injectable Solution
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yousef RezaeiSeyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran yousefrezaei1986@gmail.com hmohammadzad@gmail.com.
Kamal KhademvataniDepartment of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Behzad RahimiDepartment of Cardiology, Taleghani Hospital, Urmia University of Medical Sciences, Urmia, Iran.
Mehran KhoshfetratDepartment of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Nasim ArjmandSeyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Mir-Hossein Seyyed-MohammadzadDepartment of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran yousefrezaei1986@gmail.com hmohammadzad@gmail.com.
Urmia University · IRUrmia University of Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContrast medium-induced acute kidney injury (CIAKI) is a leading cause of acquired renal impairment. The effects of antioxidants have been conflicting regarding the prevention of CIAKI. We performed a study of vitamin E use to decrease CIAKI in patients undergoing elective coronary angiography. METHODS AND

resultsIn a placebo-controlled randomized trial at 2 centers in Iran, 300 patients with chronic kidney disease-defined as estimated glomerular filtration rate <60 mL/min per 1.73 m(2)-were randomized 1:1 to receive 0.9% saline infusion 12 hours prior to and after intervention combined with 600 mg vitamin E 12 hours before plus 400 mg vitamin E 2 hours before coronary angiography or to receive placebo. The primary end point was the development of CIAKI, defined as an increase ≥0.5 mg/dL or ≥25% in serum creatinine that peaked within 72 hours. Based on an intention-to-treat analysis, CIAKI developed in 10 (6.7%) and 21 (14.1%) patients in the vitamin E and placebo groups, respectively (P=0.037). Change in white blood cell count from baseline to peak value was greater in the vitamin E group compared with the placebo group (-500 [-1500 to 200] versus 100 [-900 to 600]×10(3)/mL, P=0.001). In multivariate analysis, vitamin E (odds ratio 0.408, 95% CI 0.170-0.982, P=0.045) and baseline Mehran score (odds ratio 1.257, 95% CI 1.007-1.569; P=0.043) predicted CIAKI.

conclusionsProphylactic short-term high-dose vitamin E combined with 0.9% saline infusion is superior to placebo for prevention of CIAKI in patients undergoing elective coronary angiography. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT02070679.

Indexed as

Acute Kidney InjuryAgedalpha-TocopherolAntioxidantsBiomarkersChi-Square DistributionContrast MediaCoronary AngiographyCreatinineDouble-Blind MethodFemaleFluid TherapyGlomerular Filtration RateHumansInfusions, ParenteralIntention to Treat Analysisalpha-TocopherolAntioxidantsBiomarkersContrast MediaCreatinineiodixanolSodium ChlorideTriiodobenzoic AcidsVitaminschronic kidney diseasecontrast‐induced acute kidney injurycoronary angiographyvitamin E

Identifiers

PMID27068631
PMCPMC4943266
OpenAlexW2309365990

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.