ArticleJournal of the American Chemical Society2016
[Ru(Me4phen)2dppz](2+), a Light Switch for DNA Mismatches.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron.Chemical biology & drug design · 2026Review
- Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications.RSC medicinal chemistry · 2026Review
- Study of the Photophysical Properties and the DNA Binding of Enantiopure [Cr(TMP)Inorganic chemistry · 2024Article
- Precious-Metal-Free COJACS Au · 2023Article
- Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects.Nucleic acids research · 2023Article
- Ruthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties.Journal of the American Chemical Society · 2023Article
- Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors.Topics in current chemistry (Cham) · 2022Review
- Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex.Journal of the American Chemical Society · 2022Article
- Adenine Radical Cation Formation by a Ligand-Centered Excited State of an Intercalated Chromium Polypyridyl Complex Leads to Enhanced DNA Photo-oxidation.Journal of the American Chemical Society · 2021Article
- Recent Advances in Schiff Base Ruthenium Metal Complexes: Synthesis and Applications.Topics in current chemistry (Cham) · 2021Review
- Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences.Inorganic chemistry · 2021Article
- AnChemical science · 2020Article
- Switch-on effect on conformation-specific arylamine-DNA adduct by cyclometalated Ir(III) complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity.Chemical science · 2019Article
- Discovery of a Ruthenium Complex for the Theranosis of Glioma through Targeting the Mitochondrial DNA with Bioinformatic Methods.International journal of molecular sciences · 2019Article
- Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)₂dppz]Molecules (Basel, Switzerland) · 2019Review
- Synthesis and photophysical studies of a multivalent photoreactive RuBeilstein journal of organic chemistry · 2018Article
- A Rhodium-Cyanine Fluorescent Probe: Detection and Signaling of Mismatches in DNA.Journal of the American Chemical Society · 2017Article
- A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites.Inorganic chemistry · 2017Article
- Combining a Ru(II) "Building Block" and Rapid Screening Approach to Identify DNA Structure-Selective "Light Switch" Compounds.ACS combinatorial science · 2017Article
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3 authors.
Funding
Abstract
[Ru(Me4phen)2dppz](2+) serves as a luminescent "light switch" for single base mismatches in DNA. The preferential luminescence enhancement observed with mismatches results from two factors: (i) the complex possesses a 26-fold higher binding affinity toward the mismatch compared to well-matched base pairs, and (ii) the excited state emission lifetime of the ruthenium bound to the DNA mismatch is 160 ns versus 35 ns when bound to a matched site. Results indicate that the complex binds to the mismatch through a metalloinsertion binding mode. Cu(phen)2(2+) quenching experiments show that the complex binds to the mismatch from the minor groove, characteristic of metalloinsertion. Additionally, the luminescence intensity of the complex with DNA containing single base mismatches correlates with the thermodynamic destabilization of the mismatch, also consistent with binding through metalloinsertion. This complex represents a potentially new early cancer diagnostic for detecting deficiencies in mismatch repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.