ArticleJournal of shoulder and elbow surgery2016
Inhibition of p38 mitogen-activated protein kinase signaling reduces fibrosis and lipid accumulation after rotator cuff repair.
Article in Journal of shoulder and elbow surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism.Stem cells translational medicine · 2026Review
- Delivery of GAS5 by LNP promotes tendon-bone healing in rotator cuff injury.Bioactive materials · 2025Article
- Identification of rare genetic variants for rotator cuff tearing and repair in high-risk pedigrees.JSES international · 2024Article
- Review
- Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.Aging cell · 2022Article
- BMP-2 Induced Signaling Pathways and Phenotypes: Comparisons Between Senescent and Non-senescent Bone Marrow Mesenchymal Stem Cells.Calcified tissue international · 2022Article
- Supraspinatus muscle architecture and physiology in a rabbit model of tenotomy and repair.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Enhanced Tendon-to-Bone Healing via IKKβ Inhibition in a Rat Rotator Cuff Model.The American journal of sports medicine · 2021Article
- Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics.Acta pharmaceutica Sinica. B · 2021Review
- Regeneration of Damaged Tendon-Bone Junctions (Entheses)-TAK1 as a Potential Node Factor.International journal of molecular sciences · 2020Review
- The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Identify differential gene expressions in fatty infiltration process in rotator cuff.Journal of orthopaedic surgery and research · 2019Article
- Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality.The American journal of sports medicine · 2019Article
- Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts.International journal of molecular medicine · 2019Article
- Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice.Journal of cachexia, sarcopenia and muscle · 2018Article
- Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.Circulation · 2017Article
- The Rotator Cuff Organ: Integrating Developmental Biology, Tissue Engineering, and Surgical Considerations to Treat Chronic Massive Rotator Cuff Tears.Tissue engineering. Part B, Reviews · 2017Article
- Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies.American journal of translational research · 2017Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe repair of rotator cuff tears is often complicated by fatty degeneration, which is the combination of lipid accumulation, fibrosis, inflammation, and muscle weakness. A signaling molecule that plays a central role in these processes is p38 mitogen-activated protein kinase (MAPK). The purpose of this study was to evaluate the ability of a small molecule inhibitor of p38 MAPK, SB203580, to reduce fatty degeneration in a preclinical model of rotator cuff injury and repair. MATERIALS AND
methodsAdult rats underwent a bilateral supraspinatus tenotomy that was repaired 30 days later. Rats were treated with SB203580 or vehicle every 2 days, with injections beginning 3 days before surgery and continuing until 7 days after surgery. Two weeks after surgical repair, muscles were analyzed using histology, lipid profiling, gene expression, and permeabilized muscle fiber contractility.
resultsInhibition of p38 MAPK resulted in a nearly 49% reduction in fat accumulation and a 29% reduction in collagen content, along with changes in corresponding genes regulating adipogenesis and matrix accumulation. There was also a marked 40% to 80% decrease in the expression of several proinflammatory genes, including IL1B, IL6, and COX2, and a 360% increase in the anti-inflammatory gene IL10. No differences were observed for muscle fiber force production.
conclusionInhibition of p38 MAPK was found to result in a significant decrease in intramuscular lipid accumulation and fibrosis that is usually seen in the degenerative cascade of rotator cuff tears, without having negative effects on the contractile properties of the rotator cuff muscle tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.