ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2016
Age and gender differences and factors related to change in health-related quality of life from before to 6 months after left ventricular assist device implantation: Findings from Interagency Registry for Mechanically Assisted Circulatory Support.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07445932 (The PALL-VAD Study), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PALL-VAD Study: Palliative Care Intervention to Improve Health Related Quality of Life for Patients With Heart Failure on Long-Term LVAD Support: A Pilot, Prospective, Randomized Trial
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical and cost-effectiveness of left ventricular assist devices as destination therapy for advanced heart failure: systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2024Pooled it
- Simulation-Based Mastery Learning Improves Patient and Caregiver Ventricular Assist Device Self-Care Skills: A Randomized Pilot Trial.Circulation. Cardiovascular quality and outcomes · 2019Trial
- Does race influence health-related quality of life outcomes in older patients who undergo advanced cardiac surgical therapies?JHLT open · 2025Article
- Assessing stress in LVAD recipients: Development of the LVAD Stress Questionnaire.The International journal of artificial organs · 2025Article
- Sex-based Differences in the Utility and Outcomes of Left Ventricular Assist Devices.Journal of the Saudi Heart Association · 2025Review
- Novel measures to assess ventricular assist device patient-reported outcomes: Findings from the MCS A-QOL study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Infections following left ventricular assist device implantation and 1-year health-related quality of life.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Change in Caregiver Health-Related Quality of Life From Before to Early After Surgery: SUSTAIN-IT Study.Circulation. Heart failure · 2023Observational
- Impact of Different Therapeutic Strategies With Left Ventricular Assist Devices on Health-Related Quality of Life During Prolonged Device-Based Support.Circulation reports · 2023Article
- Incompleteness of health-related quality of life assessments before left ventricular assist device implant: A novel quality metric.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Health-Related Quality of Life in Older Patients With Heart Failure From Before to Early After Advanced Surgical Therapies: Findings From the SUSTAIN-IT Study.Circulation. Heart failure · 2022Observational
- The Impact of Cardiac Devices on Patients' Quality of Life-A Systematic Review and Meta-Analysis.Journal of cardiovascular development and disease · 2022Review
- Research engagement and experiences of patients pre- and post-implant of a left ventricular assist device from the mechanical circulatory support measures of adjustment and quality of life (MCS A-QOL) study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies: Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study.Journal of cardiac failure · 2022Article
- Sex Differences in Recovery and Device Replacement After Left Ventricular Assist Device Implantation as Destination Therapy.Journal of the American Heart Association · 2022Article
- Health-Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN-IT Study.Journal of the American Heart Association · 2022Article
- The Impact of Clinical, Biochemical, and Echocardiographic Parameters on the Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction.International journal of environmental research and public health · 2021Article
- Exploring gender differences in trajectories of clinical markers and symptoms after left ventricular assist device implantation.European journal of cardiovascular nursing · 2021Article
- Predicting post-operative right ventricular failure using video-based deep learning.Nature communications · 2021Article
- Perceptions of Bereaved Caregivers and Clinicians About End-of-Life Care for Patients With Destination Therapy Left Ventricular Assist Devices.Journal of the American Heart Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundGaps in the literature exist regarding health-related quality of life (HRQOL) early after left ventricular assist device (LVAD) surgery. The purposes of our study were to describe HRQOL over time, by age and gender, and identify risk factors for poor HRQOL early after LVAD implant.
methodsPatients (n = 7,353) from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database received a continuous-flow LVAD as a primary implant at 133 United States hospitals. Of these, 5,640 patients had pre-LVAD HRQOL data, 3,353 patients had 6-month post-LVAD HRQOL data, and 2,748 patients had data at both times. HRQOL was measured using the EQ-5D-3L (Euro-Qol) instrument. Data were collected pre-implant and 3 and 6 months post-operatively. Statistical analyses included chi-square test, t-test, Pearson correlation coefficients, and multiple regression analysis.
resultsOverall HRQOL and dimensions of HRQOL improved from before to 6 months after device implant when examined by age and gender. However, younger patients and women reported significantly more problems regarding all dimensions before implant and significantly more problems regarding pain/discomfort and anxiety/depression at 3 and 6 months after implant. An increase in overall HRQOL from before to 6 months after implant was related to pre-implant INTERMACS Level 1. Factors related to a decrease in HRQOL from before to 6 months after implant were listed for heart transplant before surgery, comorbidities, better preoperative HRQOL, adverse events within 6 months after implant, bridge to transplant moderately likely and unlikely, and New York Heart Association Functional Classification IV at 6 months after LVAD (R(2) = 41%).
conclusionsOverall HRQOL and dimensions of HRQOL improve in sub-groups of patients from before to 6 months after surgery, although differences in improvement exist. Adverse events are risk factors for decreased HRQOL across time and support the ongoing need to improve device technology with the aim of reducing adverse events.
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