ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2016
Meningioma after radiotherapy for malignancy.
Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Stereotactic radiosurgery for vestibular schwannomas in neurofibromatosis type 2 patients: a systematic review and meta-analysis.Journal of neuro-oncology · 2022Pooled it
- Meta-analysis of adjuvant radiotherapy for intracranial atypical and malignant meningiomas.Journal of neuro-oncology · 2021Pooled it
- Radiation-induced cranial meningiomas are associated with earlier relapse: a propensity score-matched cohort study.Journal of neuro-oncology · 2026Article
- Radiation-Induced Sphenoid Wing Meningioma After Childhood Medulloblastoma: A Case Report.Cureus · 2026Article
- Radiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.Surgical neurology international · 2026Review
- Radiation-Induced Meningiomas Have an Aggressive Clinical Course: Genetic Signature Is Limited toJournal of Korean medical science · 2025Article
- Radiation-Induced Meningiomas.Advances in experimental medicine and biology · 2023Article
- Radiation-induced meningiomas (RIM) in adults: A single-centre retrospective experience.Brain & spine · 2023Article
- Clinical outcomes and considerations of gender-affirming care for transgender and gender-diverse pediatric and young adult patients with cancer.Pediatric blood & cancer · 2023Article
- Pencil-beam scanning proton therapy for the treatment of glomus jugulare tumours.Journal of medical radiation sciences · 2022Article
- De Novo Glioblastoma Masqueraded within a Hemispheric Dural Meningiomatosis: Rare Imaging Findings and Rationale for Two-Staged Resection.Journal of neurological surgery reports · 2022Article
- Medulloblastoma: an Old Diagnosis with New Promises.Current oncology reports · 2020Review
- Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors.Journal of neuro-oncology · 2020Article
- [Morbidity and mortality due to meningioma after cranial radiotherapy].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Atypical intraosseous meningioma with growth hormone deficiency and hyperparathyroidism after craniospinal irradiation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Case-based review: pediatric medulloblastoma.Neuro-oncology practice · 2017Review
- Current Clinical Brain Tumor Imaging.Neurosurgery · 2017Review
- Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas.Nature communications · 2017Article
- A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.Journal of genetic counseling · 2017Review
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Authors and funding
7 authors.
Funding
Abstract
Complications of radiation exposure have gained importance with increasing cancer survivorship. Secondary malignancies have been associated with cranial radiation exposure. We present our experience with intracranial radiation-induced meningioma (RIM) and discuss the implications of its presentation and natural history for patient management. Patients diagnosed with meningioma who had received radiation therapy between 1960 and 2014 were identified. Records were retrospectively reviewed for details of radiation exposure, previous malignancies, meningioma subtypes, multiplicity and pathologic descriptions, treatment and follow-up. Thirty patients were diagnosed with RIM. Initial malignancies included acute lymphocytic leukemia (33.3%), medulloblastoma (26.7%) and glioma (16.7%) at a mean age of 8.1years (range 0.04-33years). The mean radiation dose was 34Gy (range 16-60Gy) and latency time to meningioma was 26years (range 8-51years). Twenty-one patients (70%) underwent surgery. Of these, 57.1% of tumors were World Health Organization (WHO) grade I while 42.9% were WHO II (atypical). The mean MIB-1 labeling index for patients with WHO I tumors was 5.44%, with 33.3% exhibiting at least 5% staining. Mean follow-up after meningioma diagnosis was 5.8years. Mortality was zero during the follow-up period. Meningioma is an important long-term complication of therapeutic radiation. While more aggressive pathology occurs more frequently in RIM than in sporadic meningioma, it remains unclear whether this translates into an effect on survival. Further study should be aimed at delineating the risks and benefits of routine surveillance for the development of secondary neoplasms after radiation therapy.
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